Passive PAH and Micro-Camera Personal Monitoring System

描述(由申请人提供)： 这项研究的总体目标是开发一种新型灵敏的被动体 扩散采样器及其与微型个人便携式视频的使用 个人照射测量和评估用摄像系统(MPPVCS) 到个人空气中的致癌有机物。拟开展的研究工作，将：1. 确定不同采样条件(不同空气)下的采样率 浓度、采样持续时间、温度、湿度和面速)； 2.在并列比较中评估采样器的性能 经过验证的主动抽样法；3.评估受试者的能力 成功磨损和管理电池和磁带更换；以及4.评估 采样器和MPPVCS对捕获以下信息的组合有效性 自愿接触致癌有机物质。新型被动式采样器 由一个裸露部分组成，它由10个0.5厘米(或更长)的 多毛细管气相色谱(GC)柱(900内径40微米) 直径)。由于扩散面积(内圆柱面)值较高 对于扩散路径长度(每一列的半径)，采样率 将比传统的徽章或管式高约1000倍 扩散取样器。导管类型的几何结构将允许恒定采样 在广泛的采样条件下的采样率。此外，固定相也是 毛细管柱允许分析物直接热解吸至 分析仪器，它避免了样品被溶剂和 将灵敏度提高100倍。该取样器可以使用 在没有任何再生过程的情况下反复进行。在曝光会议期间， 轻便、不显眼的MPPVCS将附着在主体上，以获得 关于致癌有机物来源附近的实时信息和 个人在给定时间段内的活动。MPPVCS小于1 磅，可以舒适的个人佩戴。使用MPPVCS可以 减少与录像师跟踪相关的成本和负担 个人，减少与学科完成相关的负担 问卷和时间/活动日记，避免因以下原因造成的信息丢失 受试者完成失败，对他们的活动和 环境。总而言之，我们建议开发和验证一种敏感、 一种简单、经济实惠的技术，可直接测量个人暴露于 致癌有机物。新的扩散取样器和MPPVCS的联合使用将 获取暴露水平和暴露位置，以及 可能的消息来源。这种结合的方法将提高社区的准确性。 或居民对个人接触致癌物的评估 流行病学研究，并提供了更好的暴露特征 用于风险评估。

DESCRIPTION (provided by applicant): The overall objective of the research is to develop a new sensitive passive diffusion sampler and couple its use to a miniaturized personal portable video camera system (MPPVCS) for the measurement and assessment of personal exposure to carcinogenic organics in personal air. The proposed research, will: 1. determine the sampling rate under different sampling conditions (different air concentration, sampling duration, temperature, humidity, and face velocity); 2. evaluate the performance of the sampler in side-by-side comparisons with proven active sampling method; 3. evaluate the ability of subjects to successfully wear and manage battery and tape changes; and 4. evaluate the combined effectiveness of the sampler and MPPVCS to capture information about volunteer personal exposures to carcinogenic organics. The new passive sampler consists of a denuder, which is made from 10 0.5-cm (or longer) sections of a multi-capillary gas chromatography (GC) column (900 of 40-micrometer internal diameter). Due to the high value of diffusive area (inner cylindrical surface) to diffusive path length (the radius of the each column), the sampling rate will be about 1000 times higher than the traditional badge or tube-type diffusive samplers. The denuder-type geometry would allow constant sampling rates in a wide range of sampling conditions. Also, the stationary phase of the capillary column allows directly thermal desorption of analytes to an analytical instrument, which avoids dilution of the sample by solvent and increase the sensitivity by a factor of 100. The sampler can be used repeatedly without any regeneration process. During the exposure session, a lightweight, unobtrusive, MPPVCS will be attached to the subject to obtain real time information about proximity to sources of carcinogenic organics and the individual's activities at a given period of time. MPPVCS is less than 1 pound and can be comfortable for individuals to wear. The use of MPPVCS can reduce the costs and burden associated with having a videographer track the individual, reduce the burden associated with having subject completing questionnaires and time/activity diaries, and avoid information loss due to subjects' completion failure and loss of awareness of their activities and the environment. In summary, we propose to develop and validate a sensitive, simple, and cost-effective technique to directly measure personal exposure to carcinogenic organics. Joint use of the new diffusive sampler and MPPVCS would capture both the levels of exposure and the locations of exposure, and possible sources. The combined approach will improve the accuracy of community or residential assessments of personal exposure to carcinogens for prospective epidemiologieal studies, and provide the improved characterization of exposure for risk assessments.