Understanding Multiple Antibiotic Resistance in Gram Negative Bacteria

抗生素彻底改变了医学，延长了预期寿命，并与疫苗接种一起，导致许多细菌性疾病几乎被消灭。尽管如此，它们还是在临床和动物身上被过度使用。这导致许多细菌对这种抗生素产生耐药性。其直接后果是，据估计，到2050年，每年将有1 000万人死于一种耐药的、因而无法治疗的感染。多重抗生素耐药（mar）调控在抗菌素耐药性的发展中起着重要作用。这种操纵子编码了一个全球性的基因调控系统，该系统控制着大量与赋予抗生素耐药性有关的基因。这些基因中有许多已经被发现，但人们认为还有许多尚未定义。本项目将尝试发现mar操纵子的新基因靶点，从而确定抗生素耐药性的新机制。这将有可能确定新的药物靶点，并将有助于对抗抗菌素耐药性。

Antibiotics have revolutionised medicine, increased life expectancy and, alongside vaccination, have led to the near eradication of many bacterial diseases. Despite this, they have been overused in the clinic, and in animals. This had led to many bacteria becoming resistant to such antibiotics. As a direct result of this, it is estimated that 10 million people will die each year due to a resistant, and therefore untreatable, infection by the year 2050. The multiple antibiotic resistance (mar) regulon plays an important role in the development of antimicrobial resistance. The mar operon encodes a global gene regulatory system that controls a vast array of genes involved in conferring antibiotic resistance. Many of these genes have been discovered but it is thought that many remain undefined. This project will attempt to uncover new gene targets of the mar operon, and therefore identify new mechanisms of antibiotic resistance. This will potentially allow new drug targets to be identified, and will help in the fight against antimicrobial resistance.