Non-Invasive Intraocular Pressure Measurement Device

描述(申请人提供)：青光眼是导致失明的主要原因之一 在美国，占全球失明人数的15%。这个 国家眼科研究所的视力研究计划确定了 将导致青光眼的生物机制列为国家优先事项。近期 研究表明，许多形式的青光眼都有遗传成分。 一种无创、准确、可靠的LOP测量方法的研制 啮齿动物将极大地促进眼压相关基因的识别 视网膜和视神经的调节和敏感性 青光眼损害。一种非侵入性测量小鼠体内LOP的技术 支持单眼重复测量，更适用于 研究年龄、药物等因素随时间变化对眼压的影响。 露娜创新与杰克逊实验室的西蒙·约翰博士、约翰博士 凯西眼科研究所的莫里森和梅奥诊所的杰伊·麦克拉伦医生， 建议开发一种非侵入性眼压测量系统 通过同时测量啮齿动物的接触面积和应用 武力。第一阶段计划将专注于开发原型眼压计和 在进行小鼠研究之前，先用大鼠证明可行性 第二阶段计划。

DESCRIPTION (provided by applicant): Glaucoma is a leading cause of blindness in the United States and accounts for 15 percent of blindness worldwide. The Vision Research Plan for the National Eye Institute establishes identifying the biological mechanisms responsible for glaucoma as a national priority. Recent research indicates that many forms of glaucoma have a genetic component. Development of a non-invasive, accurate, and reliable method to measure lop in rodents will greatly facilitate the identification of genes involved in IOP regulation and the susceptibility of the retina and the optic nerve to glaucomatous damage. A non-invasive technique for measuring lop in mice will enable repeated measurements on a single eye and be more useful for investigating the effect of age, drugs, and other factors on IOP over time. Luna Innovations, along with Dr. Simon John at the Jackson Laboratory, Dr. John Morrison at the Casey Eye Institute, and Dr. Jay McLaren at the Mayo Clinic, propose to develop a system for non-invasive intraocular pressure measurement in rodents by providing simultaneous measurement of contact area and applied force. The Phase I program will focus on developing prototype tonometers and demonstrating feasibility with rats before advancing to mouse studies during the Phase II program.