Biochemical Detection with Single-Electron Transistors

描述：(申请人提供)本申请描述了扩展 单电子晶体管(SET)应用于生化检测。这些设备 即使对单分子结合事件也很敏感，并且使用很少 权力。它们是用标准的硅微机械加工技术制造的 生产速度快，成本低，易于适应特定的需求 应用程序要求。该项目将演示它们在监控中的使用 生物素/步骤亲和素的偶联及DNA寡聚体杂交 为了证明SET在生物学研究中的有效性 (微阵列)、医学诊断和生化战争防御。 建议的商业应用： 这种设备将在医疗保健领域具有商业潜力 诊断学、生物研究、基因组学和生化战争防御。

DESCRIPTION: (provided by applicant) This application describes the extension of single-electron transistors (SET's) to biochemical detection. Theses devices are sensitive to even single-molecular binding events and use very little power. Fabricated with standard silicon micromachining techniques, they are rapidly and inexpensively produced, and easily adaptable to specific application requirements. This project will demonstrate their use in monitoring the coupling of biotin/steptavidin, as well as DNA oligomer hybridization in order to demonstrate the effectiveness of SET's for biological research (microarrays), medical diagnostics, and biochemical warfare defense. PROPOSED COMMERCIAL APPLICATION: This device will have commercial potential in the areas of point-of-care medical diagnostics, biological research, genomics, and biochemical warfare defense.