CORE--LABORATORY SERVICES

在过去的十年中，阿尔茨海默病的研究范围急剧扩大。这一增长在很大程度上是由于新的基础研究工具的发展，使更广泛的实验室实验得以进行。我们ADRC核心设施的使命是为广泛的阿尔茨海默氏症研究人员提供高质量的资源，并通过这项活动鼓励和支持整个生物医学界的阿尔茨海默氏症研究。实验室服务的建立是为了满足我们的研究人员对获取生物资源日益增长的需求，这些资源是他们难以获得的，特别是正在迅速推进我们领域的动物模型。 为实现这一目标，为该核心确定了以下目标。 为当地的动物研究者维持育种种群 阿尔茨海默氏症和相关痴呆症的模型。 提供一个设施，使这些模型可以在 无病原微生物隔离条件 监测和质量保证基因型和遗传 动物的背景，并协助附属研究人员， 实验策略 为了保持对最古老的野生型动物的选择， 通常使用的野生型菌株，供所有成员使用， 当地的阿尔茨海默氏症研究团体 促进使用动物模型作为发现的工具。该设施的结构设计既具有一致性又具有灵活性。我们的目标是为当地研究人员提供真正需要的服务和资源。这一计划的实现将大大改善阿尔茨海默氏症研究的环境。

During the past ten years, the scope of Alzheimer's disease research has expanded dramatically. This growth has been due in large part to the development of new basic research tools that have enable a much wider range of laboratory experiments to be performed. The mission of our ADRC Core facilities is to provide high quality resources to a broad range of Alzheimer's researchers, and through this activity to encourage and support Alzheimer's disease research throughout the biomedical community. The Laboratory Services has been established to meet a growing demand from our researchers for access to biological resources that are otherwise difficult for them to obtain, in particular, the animal models that are so rapidly advancing our field. To achieve this end, the following goals have been set for this Core. to maintain breeding stock for local investigators of animal models of Alzheimer's disease and related dementias. to provide a facility in which these models can be aged under pathogen-free microisolator conditions to monitor and quality assure the genotype and genetic background of the animals and to assist affiliated researchers in strategies for experiments to maintain a selection of aged wild-type animals of the most commonly used wild-type strains for use by all members of the local Alzheimer's research community. to promote the use of animal models as a tool of discovery The structure for this facility has been designed in such a way as to provide for both consistency and flexibility. The goal is service and the provision of resources that are truly needed by our local researchers. The realization of this plan should significantly improve the climate for Alzheimer's research.