ADOPTIVE TRANSFER OF IMMUNITY IN BONE MARROW TRANSPLANTATION
ADOPTIVE TRANSFER OF IMMUNITY IN BONE MARROW TRANSPLANTATION
批准号:
6565715
负责人:
Edmund K Waller
金额:
$29.31万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-12-01 至 2002-11-30
关键词:
B cell receptor T cell receptor autologous transplantation bone marrow bone marrow transplantation clinical research drug administration rate /duration hematopoietic stem cells homologous transplantation human subject human therapy evaluation immunotherapy passive immunization tissue donors transplantation immunology vaccines
中文摘要
到目前为止,还没有研究解决供者免疫应该在什么时候进行,以便在骨髓或干细胞采集中获得最佳数量的预置B和T细胞的问题。本研究的目的是:确定接种自体和异基因骨髓供者的最佳时间间隔,以最大限度地提高骨髓移植物中抗原特异性B细胞和T细胞的频率,证明过继免疫转移到接受最近接种的异基因或自体供者骨髓的骨髓移植受者,并研究疫苗接受者的抗原特异性B细胞和T细胞反应。
英文摘要
No study to date has addressed the questions of when donor immunization should occur in order to have an optimal number of primed B and T cells in the bone marrow or the stem cell harvest. This study is designed to: determine the optimal time interval to vaccinate autologous and allogeneic BM donors in order to maximize the frequency of antigen specific B-cells and T-cells in the bone marrow graft, demonstrate transfer of adoptive immunity to BMT recipients who receive bone marrow from recently vaccinated allogeneic or autologous donors, and study antigen specific B-cell and T-cell responses in vaccine recipients.
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批准号:8837590
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资助金额:$32.37万
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Using donor pDC to optimize GvHD and GvL in allogeneic stem cell transplantation
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批准号:8630742
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资助金额:$32.37万
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财政年份:2014
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CLINICAL TRIALS- SHARED RESOURCES
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批准号:7944908
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资助金额:$7.07万
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财政年份:2009
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负责人:Edmund K Waller
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Modified Donor Lymphocytes Infusion (mDLI) for Rapid Immune Reconstitution
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批准号:8342005
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依托单位:
Project 3: Red cell transfusions and donor T-cell activation in allo-stem cell t
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资助金额:$34.2万
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财政年份:2008
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负责人:Edmund K Waller
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依托单位:
Project 3: Red cell transfusions and donor T-cell activation in allo-stem cell t
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批准号:9271224
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项目类别:
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资助金额:$33.31万
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财政年份:2008
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依托单位:
Project 3: Red cell transfusions and donor T-cell activation in allo-stem cell t
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批准号:8794967
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资助金额:$37.71万
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财政年份:2008
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负责人:Edmund K Waller
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依托单位:
Immunologic and Virologic Monitoring Laboratory Core
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批准号:8342008
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项目类别:
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资助金额:$22.55万
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财政年份:2008
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ADOPTIVE TRANSFER OF IMMUNITY IN BONE MARROW TRANSPLANTATION
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批准号:6586010
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项目类别:
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资助金额:$29.31万
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财政年份:2001
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依托单位:
ADOPTIVE TRANSFER OF IMMUNITY IN BONE MARROW TRANSPLANTATION
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资助金额:$29.31万
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财政年份:2000
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Separating Antitumor & GvHD in Allogeneic T-Cells
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ANTILEUKEMIC EFFECT OF IRRADIATED ALLOGENEIC LYMPHOCYTES
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财政年份:1998
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ANTILEUKEMIC EFFECT OF IRRADIATED ALLOGENEIC LYMPHOCYTES
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批准号:6173252
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资助金额:$23.87万
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Separating Antitumor & GvHD in Allogeneic T-Cells
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依托单位:
海外基金