CORE--HISTOLOGY FACILITY

描述（由申请人提供）：组织学核心机构（HCF） 成立于1990年，为研究人员提供组织学支持， 同行评议的癌症研究除了提供各种 技术，包括石蜡，甲基丙烯酸酯，低温恒温器，酶 组织化学和免疫组织化学，HCF已经扩展到现在提供 石蜡和低温切片的激光捕获显微切割（LCM）。后 要求HCF处理特殊项目，包括嵌入和 整个前列腺和乳房的大切片以及连续切片 整个卵巢、小肿瘤和结肠癌前病变的切片。 HCF使用新方法，使人们接受并更广泛地使用 我们癌症中心的癌症研究团体的这些方法。 组织学核心机构能够提供常规石蜡， 与更长的时间相比，在一周内为研究人员提供低温恒温器服务 通过临床设施。对该设施的需求是显而易见的， 增长率; HCF现在每季度持续处理超过7倍， 它在1990年第一季度收到的工作订单。的数量 癌症中心成员的HCF用户继续增加，84 HCF的使用量的%是由癌症中心的成员。的许多技术 由HCF提供的两种技术最初是在托马斯G. Pretlow，HCF主任，Pretlow研究实验室。普雷特洛医生就是其中之一 科学咨询委员会的九名成员，指导HCF。 该委员会包括HCF的用户，下文将详细介绍。 来自六个学术部门，大约每六个月开会一次， 审查HCF的绩效和政策。

DESCRIPTION (provided by applicant): The Histology Core Facility (HCF) was established in 1990 to provide histology support to researchers doing peer-reviewed cancer research. In addition to providing a variety of techniques, including work with paraffin, methacrylate, cryostat, enzyme histochemistry, and immunohistochemistry, the HCF has expanded to now provide laser capture microdissection (LCM) of paraffin and cryostat sections. Upon request the HCF has addressed special projects, including the embedding and sectioning of whole prostates and large sections of breast as well as serial sectioning of whole ovaries, small tumors, and colonic premalignant lesions. Use of new methodologies by the HCF has led to the acceptance and wider use of these methodologies by the cancer research community in our Cancer Center. The Histology Core Facility has been able to provide routine paraffin and cryostat services to researchers in a week compared to much longer times through a clinical facility. The need for this facility is apparent from its growth rate; the HCF now consistently processes quarterly over seven times the work orders that it received during its first quarter in 1990. The number of users of the HCF that are Cancer Center members continues to increase, and 84 percent of the HCF usage is by Cancer Center members. Many of the techniques provided by the HCF were first developed under the leadership of Thomas G. Pretlow, HCF Director, in the Pretlow research laboratory. Dr. Pretlow is one of nine members of the Scientific Advisory Committee, which directs the HCF. This committee, described in greater detail below, includes users of the HCF from six academic departments and meets approximately every six months to review the performance and policies of the HCF.