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EFFECT OF POLYUNSATURATED LECITHIN ON LIVER FIBROSIS

EFFECT OF POLYUNSATURATED LECITHIN ON LIVER FIBROSIS
多不饱和卵磷脂对肝纤维化的影响
批准号：
6586859
负责人：
STEVEN SCHENKER
金额：
$23.48万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-12-01 至 2002-11-30
来源：
https://reporter.nih.gov/project-details/6586859
关键词：
alcoholic liver cirrhosis biopsy blood chemistry clinical research clinical trial phase I fibrosis human subject human therapy evaluation inflammation lipid metabolism liver disorder chemotherapy necrosis nutrition related tag pathologic process phosphatidylcholines

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中文摘要
翻译
这是一项多中心、安慰剂对照、多不饱和卵磷脂对酒精性肝损伤患者纤维化进展为肝硬变的平行研究。它的目的是评价多不饱和卵磷脂的预防效果，并评价直接(通过肝活检)和间接(通过血液中的前肽变化)测量的肝脏胶原的相应变化。卵磷脂对脂肪变性、炎症和坏死的组织学参数的影响也将被评估。
英文摘要
This is a multicenter, placebo-controlled, parallel study of polyunsaturated lecithin on the progression of fibrosis to cirrhosis in patients with alcoholic liver damage. Its objective is to evaluate the preventive effect of polyunsaturated lecithin and to assess the corresponding changes in hepatic collagen measured directly (by liver biopsy) and indirectly (by propeptide changes in the blood). The effect of lecithin on histologic parameters of steatosis, inflammation, and necrosis will also be assessed.
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FOOD RESTRICTION ON ACETAMINOPHEN METABOLISM & DISPOSITION
EFFECT OF POLYUNSATURATED LECITHIN ON LIVER FIBROSIS
FOOD RESTRICTION ON ACETAMINOPHEN METABOLISM & DISPOSITION
EFFECT OF POLYUNSATURATED LECITHIN ON LIVER FIBROSIS
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