NIDA CLINICAL TRIALS NETWORK: UCLA RESEARCH NODE

这并不是说药物滥用治疗没有取得进展-相反，问题是这些进展没有转化为社区一级的治疗系统。 这种“脱节”（Leshner）或“差距”（医学研究所）促使NIDA建议建立一种机制，以促进研究成果向社区的转移。 拟议的临床试验网络（CTN）就是这一建议的结果。 正如设想的那样，拟议的UCLA CTN节点将进行和参与药物滥用依赖的行为，药理学和联合行为和药理学治疗试验，并将在CTN节点内和跨CTN节点进行治疗实践研究。 加州大学洛杉矶分校节点将有效地汇集了一个优秀的调查小组和一系列不同的社区治疗计划的专业知识，以应对CTN的设想需求。 该小组在组织和开展多中心研究方面有着良好的记录，并且一方面与NIDA和全国各地的其他调查人员合作，另一方面与社区团体合作。 该提案概述了现有的临床基础设施，其中包括南加州的社区治疗诊所系统，并描述了与其他四个社区诊所的进一步合作关系，每个诊所都对CTN有独特的贡献。 提议详细说明了拟议小组的培训和研究经验，以及可以扩大以满足网络需要的现有培训和研究基础设施。 该提案概述了该集团在过去几十年中成功使用的行政基础设施，该基础设施可以得到加强，以满足CTN的要求。 最后，提案提出了三个研究概念供指导委员会审议。 这些概念涵盖了该小组的经验和目前对适合在CTN内研究的项目的思考。

It is not that substance abuse treatment has made no advances - instead, the problem is that these advances have not translated into the treatment system at the community level. This "disconnect" (Leshner) or "gap" (the Institute of Medicine) prompted the recommendation that NIDA establish a mechanism to facilitate transfer of research findings into the community. The proposed Clincial Trial Network (CTN) is the result of that recommendation. As envisioned, the proposed UCLA CTN Node will conduct and participate in behavioral, pharmacological, and combined behavioral and pharmacological treatment trials for drug abuse dependence and will conduct research on treatment practices within and across CTN Nodes. The UCLA Node would effectively bring together an outstanding group of investigators and a diverse array of community treatment programs with the expertise to respond to the envisioned needs of the CTN. The group has a track record for organizing and conducting multi-center studies and a successful history of working collaboratively with NIDA and other investigators across the nation on the one hand, and with community groups on the other. This proposal outlines an existing clinical infrastructure, which encompasses a system of community-based treatment clinics in Southern California, and describes a further partnership with four other community-based clinics, each with unique contributions for the CTN. The proposal details the training and research experience of the proposed group and the established training and research infrastructure that can be expanded to accommodate the needs of the Network. The proposal outlines an administrative infrastructure that the group has used successfully for the past several decades and which can be enhanced to meet CTN requirements. Finally, the proposal presents three research concepts for the Steering Committee's consideration. These concepts exemplify the group's experience and current thinking about projects that would be suitable for study within the CTN.