Factors that influence the avian T and B cell repertoire

适应性免疫系统在其T和B细胞中具有显著的多样性，每个独特的克隆能够对特定的抗原作出反应。考虑到这一点，高通量测序（HTS）技术为在健康和疾病的背景下检查T和B细胞库开辟了新的途径。然而，这项技术尚未应用于分析鸟类的适应性免疫库，尽管它们对粮食安全或动物健康等全球问题很重要。本项目的目的是应用基于HTS的方法来研究禽类宿主适应性免疫谱的各种驱动因素的影响。因此，将评估微生物定殖、疫苗接种和感染性攻击等因素对T和B细胞谱的影响。这项研究的结果将提供有关禽类免疫系统的有价值的信息，同时也有可能指导家禽业当前和未来的实践。

The adaptive immune system possesses a remarkable diversity in its T and B cells, with each unique clone being able to respond to a specific antigen. With this in mind, high-throughput sequencing (HTS) technology has opened new avenues for examining the T and B cell repertoire in the context of both health and disease. However, this technology has not yet been applied to analyse the adaptive immune repertoire of birds, in spite of their importance to global issues such as food security or animal health. The aim of this project is to apply an HTS-based methodology to study the impact of various drivers of the adaptive immune repertoire of avian hosts.Therefore, factors such as microbial colonisation, vaccination, and infectious challenge will be evaluated in terms of their effects on the T and B cell repertoire. The outcomes of this research will provide valuable information about the avian immune system, while also having the potential to guide current and future practices in the poultry sector.