IMPROVEMENT OF ANIMAL HEALTH PROGRAM

该申请要求资金，以满足洛克菲勒大学的集中实验室动物计划的改善的短期和长期目标。要求为三个主要项目提供资金，每个项目对动物健康都有重大影响。这些措施包括安装感应卡读取室出入系统、提供感应活动的夜室灯光控制系统，以及安装通风架，将动物安置在微型隔离笼内。限制房间进入将提供更高水平的生物安全，减少无意中造成房间污染的机会，并作为调整房间卫生时间表的监测装置。运动敏感的光覆盖将使用夜间红灯系统，以尽量减少入侵对夜间周期的影响，从而使动物保持在一个更生理状态。通风笼通过HEPA过滤的供应空气增加微环境安全性，通过增加空气交换减少笼内有毒气体积聚，并允许更有效的住房。后一个系统还将容纳来自一个卫星设施的动物，而一个新的中央设施正在建设中。

This application requests funds to meet the short- and long-term goals of The Rockefeller University's improvement of the centralized laboratory animal program. Funds are requested for three major projects, each of which has substantial implications for animal health. They include the installation of a proximity card-reading room access system, provision of a motion-sensitive evening room light over-ride system, and installation of ventilated racks housing animals in microisolator cages. Restrictive room access will provide a higher level of biosecurity, reduce opportunities for inadvertent room contamination, and serve as a monitoring device to adjust room sanitation schedules. Motion-sensitive light over-rides will use an evening red light system to minimize the impact of intrusion on nocturnal cycles, thus maintaining animals in a more physiological state. The ventilated caging increases microenvironmental safety through HEPA-filtered supply air, reduced in-cage noxious gas accumulation via increased air changes, and allows for more efficient housing. The latter system will also accommodate animals from a satellite facility while a new central facility is under construction.