SUPPLEMENT-ANIMAL FACILITY IMPROVEMENT

描述（由申请人提供）： 通过RCMI倡议，纽约市立大学创建了细胞和分子发育基础研究中心（CSCMBD）。 该中心建立在RCMI支持领域的学院现有优势基础上，通过增加新的研究活跃的教师来丰富。 现在有21名研究人员参与该中心的三个科学领域：1）生物分子结构和功能，2）基因表达和调控，以及3）神经生物学。 除了主要的科学领域，该中心的教师的独特技能被编组，以发展免疫学小组。 主要设备的采购和中央设施的建立进一步加强了中心内的活动。 未来，对遵守美国农业部动物福利法和卫生与公众服务部有关实验室动物护理和使用的政策以及获得AAALAC认证的要求显著增加。 该应用程序的主要重点是翻新，维修和升级动物设施。 为了表示对RCMI计划的支持，并作为机构承诺的一部分，学院将捐款163万美元，以分担该项目的费用。 本申请的具体目的是改善现有的动物设施。 有三个主要目标：1）用一个集中更新的供暖、通风和空调（HVAC）系统取代现有的不充分的独立式空气处理装置; 2）创建具有清洁和脏分级功能分离的笼清洗和分级区域，和3）重新设计和翻新科学大楼七楼和八楼的现有动物园，以便更有效地利用空间，现在和未来的动物需求。 这将包括翻修另一个用于重新安置啮齿动物的房间，并为转基因小鼠建立啮齿动物屏障设施。

DESCRIPTION (provided by applicant): Through the RCMI initiative the CUNY created the Center for the Study of the Cellular and Molecular Basis of Development (CSCMBD). The Center, built on the existing strengths of the College in the RCMI-supported areas, was enriched by the addition of new research active faculty members. There are now 21 researchers participating in the Center grouped in three scientific areas: 1) Biomolecular Structure and Function, 2) Gene Expression and Regulation, and 3) Neurobiology. In addition to the main scientific areas, the unique skills of the Center's faculty were marshaled to develop an immunology subgroup. Major equipment purchases and the creation of central facilities further enhanced the activity within the Center. In the future, the demands for compliance with the United States Department of Agriculture Animal Welfare Act and Department of Health and Human Services policies relating to the care and use of laboratory animals as well as gaining AAALAC accreditation has significantly increased. The major focus of this application is to renovate, repair and upgrade the animal facility. To show its support for the RCMI program and as a part of institutional commitment, the College will contribute $1.63 million to share the cost of this project. The specific aim of this application is to improve the existing animal facility. There are three major objectives: 1) replace existing inadequate freestanding air handling units with one centralized updated heating, ventilation, and air-conditioning (HVAC) system; 2) create a cage washing and staging area with separation of clean and dirty staging functions, and 3) redesign and renovate the existing vivarium on the seventh and eighth floors of the Science Building for more efficient use of space and to better accommodate present and future animal needs. This will include the renovation of an additional room for the relocation of rodents and the creation of a rodent barrier facility for transgenic mice.