New Psychometric Methods for Substance Abuse Research

描述：(申请人提供) 这是一项K05高级科学家研究事业奖(RCA)的申请 竞争延续#5 K05 DA00017。建议的具体目标 五年研究计划如下： 1.为药物滥用研究开发新的心理测量方法； 2.将这些新开发的方法应用于重要的药物滥用数据集； 3.在方法上产生切实的改进； 4.创建非技术论文和教程，以改进药物方法学 虐待研究；以及 5.向药物滥用和健康研究人员和政府机构提供建议 方法论。 研究项目是针对新的多元变量的开发 心理测量学和统计学技术为改进带来了特殊的希望 心理社会、社会、行为、流行病学和 关于药物使用和滥用的功能成像健康相关研究。方法： 强有力地分析实验性和非实验性药物滥用数据，这可能 包含选择性、异常值情况、任意分布、 测量、非标准抽样计划、小样本、相依观测、 等将被开发。特别关注结构方程。 可能涉及调解和调解人关系中的潜在变量的模型。 最优小样本、缺失数据、稳健、多水平非正态、自举 功能成像、超级计算机的研究方法是一个特别关注的问题。而当 根据这项拨款，不会收集任何数据，新开发的技术将 被广泛评估其对药物滥用研究的实际意义 通过利用高质量的数据解决药物滥用方面的重要实质性问题 与NIDA/UCLA计划项目赠款P01 DA01070相关联获得，通过 与脑图研究人员和国家活性物质合作 虐待研究人员致力于他们自己的项目，以及通过与 NIDA和其他与健康相关的机构。在此基础上开发的方法 格兰特还将被广泛传播。

DESCRIPTION: (provided by applicant) This is a request for a K05 Senior Scientist Research Career Award (RCA) as a competing continuation of #5 K05 DA00017. The specific aims of the proposed five-year research program are the following: 1. Develop new psychometric methods for drug abuse research; 2. Apply these newly developed methods to important drug abuse data sets; 3. Generate practical improvements in methodology; 4. Create nontechnical papers and tutorials to improve methodology in drug abuse research; and 5. Advise drug abuse and health researchers and government agencies on methodology. The research program is directed towards the development of new multivariate psychometric and statistical techniques that hold special promise for improving the quality of psychosocial, social, behavioral, epidemiological, and functional imaging health-related research on drug use and abuse. Methods for robustly analyzing experimental and nonexperimental drug abuse data that may contain selectivity, outlier cases, arbitrary distributions, errors in measurement, nonstandard sampling plans, small samples, dependent observations, etc. will be developed. Special attention is given to structural equation models that may involve latent variables in mediation and moderator relations. Optimal small sample, missing data, robust, multilevel nonnormal, bootstrap, functional imaging, supercomputer research methods are a special focus. While no data will be gathered under this grant, the newly developed techniques will be extensively evaluated for their practical relevance to drug abuse research by addressing important substantive issues in drug abuse on high-quality data obtained in association with NIDA/UCLA program project grant P01 DA01070, via collaboration with brain mapping researchers and nationally active substance abuse researchers working on their own projects, as well as by cooperation with NIDA and other health-related agencies. Methods that are developed under this grant also will be widely disseminated.