Continuous, Automated, Mandibular Distractor

名称：Physical Sciences Inc. (PSI)建议与哈佛口腔颌面外科系的临床医生合作，开发一种用于下颌骨牵引成骨（DO）的创新设备。DO挖掘身体的骨再生能力，以填补骨间隙，该间隙通过机械牵引器逐渐扩大。提出的概念将使用微型液压产生一个全埋式致动器能够产生弯曲的牵引轨迹。该器械将允许骨骼扩张，而无需穿过皮肤的连杆，通过自动化运动过程减少患者责任，允许临床医生随着治疗进展改变牵引轨迹，并通过使运动几乎连续来减少牵引时间。该计划将强调的能力，使曲线牵引轨迹。几个关键的工程创新将使新的分心。其中包括：微和微型阀门技术、液压能量存储、用于体内编程和控制的低功率RF链路以及用于复杂轨迹的多致动器设计。在第一阶段，PSI将确定关键技术挑战的解决方案，构建原型设备，并通过将其植入猪尸体来证明可行性。第二阶段计划将包括构建一个完整的埋藏式牵引系统，并在活体动物身上进行测试。

DESCRIPTION: Physical Sciences Inc. (PSI) proposes to partner with clinicians in the Harvard Department of Oral and Maxillofacial Surgery to develop an innovative device for distraction osteogenesis (DO) of the mandible. DO taps the bone regeneration ability of the body to fill a bone gap that is gradually expanded with a mechanical distractor. The concept proposed will use miniature hydraulics to produce a fully buried actuator capable of producing curved distraction trajectories. The device will allow skeletal expansion without linkages that pass through the skin, reduce patient responsibility by automating the motion process, permit clinicians to alter the distraction trajectory as treatment progresses, and reduce distraction time by making the motion nearly continuous. The program will emphasize the ability to make curvilinear distraction trajectories. Several key engineering innovations will make the new distractor possible. These include: micro- and miniature valve technologies, storage of hydraulic energy, a low-power RF link for in vivo programming and control, and multi-actuator design for complex trajectories. In Phase I, PSI will identify solutions to critical technology challenges, build a prototype device, and demonstrate feasibility by implanting it in a porcine cadaver. The Phase II program will include constructing a complete buried distraction system and testing in a live animal.