Cationic Polymers for Gene Delivery

阳离子聚合物提供了一种更安全的替代病毒载体，具有引起免疫反应的缺点。具体来说，带正电的聚合物有能力结合带负电的遗传物质，从而产生中性或略带正电的聚合物/ DNA复合物，可以通过疏水和带负电的细胞膜。因此，基因被传递到细胞中。本论文的目的将是确定重要的设计标准。因此，定义明确的不同结构、组成和摩尔质量的阳离子聚合物将被合成并系统地研究其传递遗传物质的能力。

Cationic polymers provide a safer alternative to viral vectors that have the disadvantage of causing immune response. Specifically, positively charged polymers have the ability to bind the negatively charged genetic material, hence creating a neutral or slightly positively charged polymer / DNA complex that can pass through the hydrophobic and negatively charged cellular membrane. Thus, the gene is delivered into the cell.The aim of this thesis will be to identify important design criteria. Thus well-defined cationic polymers of different architectures, compositions and molar masses will be synthesised and systematically investigated in terms of their ability to delivery genetic material.