The Variable Expression of CD33 on Leukemic Stem Cells

描述（由申请人提供）： 这是一份K08奖项的申请。 候选人是密歇根大学医学中心血液和骨髓移植项目的初级教员。 贝克尔博士的长期目标是成为白血病和干细胞生物学领域的独立实验室研究者。 该应用程序详细介绍了一个四点计划，该计划将为贝克尔博士提供必要的工具，以发展他的研究生涯，使他能够实现这一目标。 首先，贝克尔博士将通过参加密歇根大学研究生院的几门课程，获得分子生物学和发育生物学方面的高级概念和理论培训，特别强调致癌作用和干细胞生物学。 第二，Becker博士将通过完成关于急性髓系白血病中白血病干细胞表达CD33的研究项目获得额外的研究技能和技术。 贝克尔博士已经取得了令人印象深刻的初步数据，这些数据已提交给一家领先的同行评审期刊发表。 第三，贝克尔博士将通过参加BMT研究研讨会和会议、参加国家会议和编写手稿，获得成功职业所需的书面和口头高级沟通技能。 第四，申请人在整个获奖过程中的进展将由高级研究人员和学术领导人组成的咨询委员会监督。 申请人的赞助商保证，贝克尔博士的80%的努力将致力于他的研究期间，这个奖项。

DESCRIPTION (provided by applicant): This is an application for a K08 award. The candidate is a junior faculty member in the Blood and Marrow Transplantation Program at the University of Michigan Medical Center. Dr. Becker's long term goal is to become an independent laboratory investigator in the field of leukemogenesis and stem cell biology. This application details a four point program that will provide the necessary tools for Dr. Becker to develop his research career such that he can achieve this goal. First, Dr. Becker will obtain advanced conceptual and theoretical training in molecular biology and developmental biology with particular emphasis on carcinogenesis and stem cell biology by participating in several courses in the University of Michigan graduate school. Second, Dr. Becker will acquire additional research skills and techniques through the completion of his research project regarding the expression of CD33 on leukemic stem cells in Acute Myelogenous Leukemia. Dr. Becker has already achieved impressive preliminary data that have been submitted for publication in a leading peer reviewed journal. Third, Dr. Becker will acquire advanced communication skills, both written and oral, required for a successful career through participation in BMT research seminars and conferences, participation in national meetings and the preparation of manuscripts. Fourth, the applicant's progress throughout the award will be monitored by an advisory committee of senior researchers and academic leaders. The applicant's sponsor guarantees that 80% of Dr. Becker's effort will be devoted to his research for the period of this award.