Longitudinal Study--Sleep-Disordered Breathing/Pregnancy

描述(由申请人准备)：应聘者计划/培训： 以病人为中心的睡眠医学和流行病学研究。培训将会 包括在密切指导下完成研究方案，高级 流行病学课程工作中以患者为中心的研究高级培训 睡眠医学和呼吸神经生物学。 环境：宾夕法尼亚大学是一个特别适合的环境 获得这个训练奖。睡眠与呼吸神经生物学中心 将在以患者为中心的研究中提供指导经验。《中心》 临床流行病学和生物统计学将提供高级教学 训练。 研究：怀孕期间，包括孕期体重在内的生理变化 发生可能使妇女患上更大的 睡眠呼吸障碍(SDB)。打呼噜，这是SDB的常见症状， 在孕妇中是一种常见的抱怨，习惯于 多达23%的妇女在怀孕的最后三个月结束时。 女性打鼾者可能表现为睡眠呼吸障碍 在很大程度上仍未被开发。在一般人群中，基线肥胖和 体重增加都与睡眠障碍的风险增加有关 呼吸。我们的核心假设是怀孕是一段 女性睡眠呼吸紊乱加速发展，在这种情况下 基线体重升高的女性增加的程度可能更大 体重指数(BMI)或孕期体重增加更多。该协议检查 睡眠呼吸紊乱事件在女性中的数量是否增加 在怀孕期间以及基线体重状况和体重增加 孕期影响SDB的程度。这项研究的具体目的 建议有：1)检验呼吸紊乱指数的假设 (RDI)，衡量每小时异常呼吸事件的数量 睡眠，在怀孕期间增加；并确定是否 肥胖女性的增加程度更大；以及2)确定特定的 影响临床有意义的风险的临床特征 SDB的严重性增加。

DESCRIPTION (prepared by applicant): Candidate's Plans/Training: The patient-oriented research in sleep medicine and epidemiology. Training will include closely mentored completion of the research protocol, advanced epidemiological course work in patient-oriented research advanced training in sleep medicine and respiratory neurobiology . Environment: The University of Pennsylvania is a uniquely suited environment for this training award. The Center for Sleep and Respiratory Neurobiology will provide a mentored experience in patient-oriented research. The Center for Clinical Epidemiology and Biostatistics will provide advanced didactic training. Research: During pregnancy, physiologic changes including gestational weight gain take place that may place women at increased risk for the development of sleep-disordered breathing (SDB). Snoring, which is a common symptom of SDB, is a frequent complaint among pregnant women, experienced on a habitual b y as many as 23 percent of women by the end of the final trimester of pregnancy. The possibility regnant women snorers may manifest sleep-disordered breathing has remained largely unexplored. In general population, baseline obesity and weight gain are both associated with an increased risk for sleep-disordered breathing. It is our central hypothesis that pregnancy is a time of accelerated development of sleep disordered breathing in women, in which the degree of increase is likely to be larger in women with elevated baseline body mass index (BMI) or greater gestational weight gain. This protocol examines whether the number of sleep-disordered breathing events increases in women over the course of pregnancy and how baseline weight status and weight gain during pregnancy impact the degree of SDB. The specific aims of the study proposal are: 1) to test the hypothesis that the respiratory disturbance index (RDI), a measure of the number of abnormal respiratory events hourly during sleep, increases over the course of pregnancy; and to determine whether the degree of increase is greater in obese women; and 2) to identify specific clinical characteristics that influence the risk for clinically significant increases in the severity of SDB.