Boron-Directed C-H Activation: Double Direct Functionalisation of CH Bonds

有机分子含有多个碳氢（C-H）键，因此仅在一个位点实现选择性反应非常具有挑战性。C-H键的金属催化反应可以为完全未活化的散装化学品（烃，芳烃）的功能化和复杂分子（如药物）的后期功能化提供潜在的强大方法，前提是可以实现选择性。在这个项目中，我们将研究一种新的方法，我们将使用有机分子中的硼基团来控制金属催化的C-H官能化反应的选择性。将合成一系列结构新颖的硼化合物，并探索它们在C-H活化反应中的反应性。由于碳-硼键在进行各种高选择性化学反应的能力方面具有非常多的用途，因此我们的新C-H官能化反应的产物将被视为有机化学的有用构建块。该研究项目福尔斯属于EPSRC物理科学研究主题中的催化和合成有机化学领域。该项目中开发的技术可以通过促进新型药物的未来设计和开发，在EPSRC的医疗保健技术和制造未来主题中找到应用。

Organic molecules contain multiple carbon-hydrogen (C-H) bonds, so achieving a selective reaction at only one site is very challenging. Metal-catalysed reactions of C-H bonds can offer a potentially powerful approach both to the functionalisation of entirely unactivated bulk chemicals (hydrocarbons, arenes), and for late-stage functionalisation of complex molecules such as pharmaceuticals, provided selectivity can be achieved. In this project, we will examine a new approach where we will use a boron group in an organic molecule to control the selectivity of metal-catalysed C-H functionalisation reactions. A range of structurally novel boron compounds will be synthesised and their reactivity in C-H activation reactions explored. As carbon-boron bonds are very versatile in their ability to undergo a variety of highly selective chemical reactions, the products of our new C-H functionalisation reactions will then be examined as useful building blocks for organic chemistry.The research project falls within the EPSRC areas of Catalysis and Synthetic Organic Chemistry within the Physical Sciences research theme. The technology developed in this project could find application within the EPSRC themes of Healthcare Technologies and Manufacturing the Future by facilitating the future design and development of novel pharmaceuticals.