Echocardiographic assessment of acute and chronic effects of exercise on cardiac function - from physiology to clinical practice

该项目将把医学统计学和临床试验设计、运动生理学和医学结合在一个综合研究中。我们建议建立和分析动态的多器官数学模型，以提供一种手段来阐明患有姑息性先天性心脏病(双室修复组)的儿科患者的生理系统和过程之间的定量关系。在儿童接受矫正心脏手术后，心肺功能是成功预后的重要因素，但其处方未得到充分利用。该项目将使用系统评估、心肺和超声心动图测试以及干预措施，为患者和临床医生提供定制的生物医学信息。

This project will combine medical statistics and clinical trial design, exercise physiology and medicine in one integrated study. We propose to construct and analyse dynamic, multi-organ mathematical models to provide a means to elucidate the quantitative relationships between physiological systems and processes for paediatric patients with sub-groups of palliated congenital heart disease (biventricular repair groups).After a child has undergone corrective heart surgery, cardiorespiratory fitness is an important factor of successful outcome, but its prescription is under-utilised. This project will use systematic reviews, cardiorespiratory and echocardiography testing and an intervention providing bespoke biomedical information for the patient and clinicians.