CORTICAL CONTROL OF MOVEMENT

描述：(改编自《调查者摘要》)：本报告的目标 研究是为了了解运动皮质在控制运动中的作用。 尽管在过去的两个世纪里付出了巨大的努力，但仍然没有什么 关于运动皮质自愿控制机制的共识 动静。最近，肌间触须的探索性运动 作为一种很有前途的、更简单的解决方案的模型系统 这个问题。然而，由于缺乏关于这一问题的数据，进展受到限制 负责运动行为的途径和机制。根据我们的发现， 我们假设小细胞网状结构中的前运动神经元 是控制探索性搅拌的网络的关键部分，而 运动皮质通过对这些前运动神经元的作用来调节快动。 几个假说将用电生理学和 体内和体外的神经解剖学方法。拟议的研究将 为了解运动皮质的正常功能提供相关数据， 以及先天或后天神经系统疾病的潜在过程 导致感觉-运动障碍。

DESCRIPTION: (Adapted from the Investigator's Abstract): The goal of this research is to understand the role of the motor cortex in controlling movement. Despite intense efforts over the last two centuries, there is still little consensus about the mechanisms by which the motor cortex controls voluntary movements. Recently, exploratory movements of the mystacial vibrissae ("whisking") have emerged as a promising, simpler model system for addressing this issue. However, progress has been limited by the lack of data on the pathways and mechanisms responsible for the motor act. Based on our findings, we hypothesize that pre-motoneurons in the parvocellular reticular formation are a key part of a network that controls exploratory whisking, and that the motor cortex modulates whisking by its action on these pre-motoneurons. Several hypotheses will be tested using electrophysilolgical and neuroanatomical approaches in vivo and in vitro. The proposed studies will provide data pertinent to understand the normal functions of the mortor cortex, and the processes underlying congenital or acquired neurological diseases resulting in sensory-motor deficits.