PhD in bio-medical applications of robust coordination cages

该项目将采用关键的原理验证结果（卢斯比，Archibald及其同事：JACS 2018，140，16877），这些结果表明，使用新型放射性示踪剂封装方法，可以将稳健的协调笼用于体内SPECT成像。在过去的12个月里，这项技术的知识产权保护也已提交。卢斯比和Hulme小组也一直在开发笼式探针，其结合生物正交炔单元用于亚细胞成像，从而补充体内SPECT模式。该拟议项目将通过（a）寻求开发用于不同疾病状态的靶向分子成像的功能化类似物：（B）扩展到PET探针和治疗剂，以及（c）开发拉曼笼成像以了解这些独特类别化合物的固有分子靶点来促进这些应用。

This project will take forward key proof-of-principle results (Lusby, Archibald and co-workers: JACS 2018, 140, 16877) that show robust coordination cages can be exploited for in vivo SPECT imaging using a novel radiotracer encapsulation method. IP protection for this technology has also been submitted in the past 12 months. The Lusby and Hulme groups have also been developing cage probes that incorporate bio-orthogonal alkyne units for sub-cellular imaging thus complementing in vivo SPECT modality. This proposed project will further these applications by (a) seeking to develop functionalised analogues for the targeted, molecular imaging of different disease states: (b) expand to PET probes and therapeutics and (c) to develop raman-cage imaging to understand the inherent molecular targets of these unique class of compounds.