Training in Biologic Threat Agents

描述（由申请人提供）：公共卫生措施已经成功地减少了由许多高致病性病原体引起的疾病发病率，但很明显，我们很容易受到故意将传染性病原体引入环境的影响。这项培训补助金将利用以下重点领域的研究优势：发病机制、毒素生物学、疫苗研究和感染和免疫动物模型、肺生物学、传染病和宿主反应、蛋白质组学/基因组学/基因阵列、快速检测和环境工程。Alison Weiss博士将担任该培训基金的主任，George Deepe博士将担任联合主任。来自辛辛那提大学医学院、工程学院和化学系以及儿童医院医疗中心和退伍军人管理医疗中心的加州大学教师的才华横溢的互动研究人员将加入他们的行列。培训师资队伍包括：教授21人，副教授8人，助理教授6人。培训教员可获得的外部资金数额令人印象深刻。资助前、博士后研修生2年。他们将从辛辛那提大学录取的对生物恐怖主义研究感兴趣的个人中招募，并承诺与一名培训资助教员合作。医学博士培训生将获得为期三年的支持，并将被招募为住院医生或研究员培训计划的一部分，其中包括亚专科临床培训。第一年将招收两名博士预科生，此后每年增加三名新学员。第一年招收2名博士博士后，以后每年增加1名。对于医学博士博士后，我们第一年将招收一名，之后每年增加一名。辛辛那提大学医学综合体的特殊资源包括：全新的、最先进的P3生物防护设施、蛋白质组学设施、DNA核心实验室、最先进的核磁共振设施、即将上线的x射线晶体学设施，以及NIH资助的以儿童医院为中心的疫苗测试部门。

DESCRIPTION (provided by applicant): Public health measures have successfully reduced the incidence of disease due to many highly pathogenic agents, but it has become clear that we are vulnerable to deliberate introduction of infectious agents into the environment. This training grant will draw on research strengths in the following focus areas: Pathogenesis, Toxin Biology, Vaccine Studies and Animal Models of Infection and Immunity, Pulmonary Biology, Infectious Diseases and Host Response, Proteomics/Genomics/Gene Arrays, and Rapid Detection and Environmental Engineering. Dr. Alison Weiss will serve as Director, and Dr. George Deepe will serve as Co-Director of this training grant. They will be joined by highly talented and interactive researchers from the University of Cincinnati College of Medicine, College of Engineering, and the Department of Chemistry, as well as UC faculty affiliated with the Children's Hospital Medical Center and the Veteran's Administration Medical Center. The training faculty includes: 21 Professors, eight Associate and six Assistant Professors. An impressive level of external funding is available to the training faculty. Pre- and Postdoctoral PhD trainees will be supported for two years. They will be recruited from individuals admitted to the University of Cincinnati who are interested in bioterrorism research, and committed to working with a training grant faculty member. The MD trainees will be supported for three years, and will be recruited as part of their resident or fellowship-training program, which includes sub-specialty clinical training. Two predoctoral students will be enrolled the first year, with three new trainees added each year thereafter. Two PhD postdoctoral trainees will be enrolled in first year, with one new trainee added each year thereafter. For MD postdoctoral trainees, we will accept one individual the first year and one additional individual in each of the following years. Special resources at the University of Cincinnati Medical Complex include: a brand-new, state-of-the-art P3 Bio-containment facility, proteomics facility, DNA core lab, state-of-the-art NMR facility, X-ray crystallography facility to come on line, and an NIH funded Vaccine Testing Unit centered at Children's Hospital.