Comprehensive Training Grant in Bone Biology and Disease

描述（由申请人提供）：此修订后的申请 在UAB骨生物学和疾病的综合研究培训计划 提供发展所需的严格的跨学科教育， 独立研究科学家在这一领域。培训计划基于 UAB代谢性骨病中心（主任：J. McDonald，医学博士），这 已被资助为5个国家研究核心中心（P30）之一。25名教师 培训计划的成员是根据他们的互补性选择的。 临床和基础研究的研究专长，动态研究计划， 培训记录。由于该计划的跨学科性质， 教师已经确定了立即可用的合作项目（58） 可用于招聘和指导。基础研究项目包括 利用各种方法和技术分析生物学基础， 骨质流失、骨质疏松症、其他代谢性骨病和糖皮质激素 引起的骨丢失;牙周病;转移到骨的癌症;以及 生物材料/植入物研究。临床研究项目（流行病学， 预防、结果和有效性研究;发展诊断方法; 和临床试验）利用临床教师的参与， 长期、多机构研究，包括老年和儿科研究 人口。培训计划将由McDonald博士（主席： 病理学）由两名副主任（T。林肯博士; L.莫兰， 医学博士），负责制定个人培训计划， 研究和教学组成部分的整合，以及对正式课程的监督 咨询委员会（M。Jeffcoat医学博士L.卢卡斯博士， R. Mayne博士，J. Murphy Ulrich博士，K. Saag，医学博士），谁将成为 负责招聘，正式申请的竞争性审查，以及 监督学员的进度。基础研究的受训人员将被要求 参加全部或部分综合生物医学科学计划（主任： 林肯），提供必要的器官和细胞基础科学培训 从分子生物学和遗传学分析方法转变为 临床相关的、基于问题的研究。K30翻译研究 项目（PI：莫兰）为临床研究者提供知识 和管理技能的设计和完成所必需的 信息丰富的临床研究和试验，以及国家的背景， 艺术基础科学知识。申请资助三名博士预科生， 三个博士后。博士前学员将在IBS注册， 生物医学工程，细胞和分子生物学，或医学博士/博士研究生 在UAB的节目。

DESCRIPTION (provided by applicant): This revised application for a comprehensive Research Training Program in Bone Biology and Disease at UAB offers the rigorous interdisciplinary education required for the development of independent research scientists in this field. The Training Program is based in the UAB Center for Metabolic Bone Disease (Director: J. McDonald, M.D.), which has been funded as 1 of 5 national Research Core Centers (P30). The 25 faculty members of the Training Program have been selected based on their complementary research expertise in clinical and basic research, dynamic research programs, and training records. Due to the interdisciplinary nature of the Program, the faculty has defined collaborative projects (58) that are available immediately and can be used in recruitment and guidance. Basic research projects include the use of approaches and technologies in the analysis of the basic biology of bone loss; osteoporosis, other metabolic bone diseases, and glucocorticoid induced bone loss; periodontal disease; cancer metastatic to bone; and biomaterials/implant research. The clinical research projects (epidemiology, prevention, outcomes, and effectiveness studies; development of diagnostics; and clinical trials) exploit the participation of clinical faculty in long term, multi institutional studies, including geriatric and pediatric populations. The Training Program will be administered by Dr. McDonald (Chair: Pathology) assisted by two Associate Directors (T. Lincoln, Ph.D.; L. Moreland, M.D.), who will be responsible for development of individual training plans, integration of research and didactic components, and oversight of formal requirements, and an Advisory Committee (M. Jeffcoat, D.M.D., L. Lucas, Ph.D., R. Mayne, Ph.D., J. Murphy Ulrich, Ph.D., K. Saag, M.D.), who will be responsible for recruitment, competitive review of formal applications, and oversight of trainees progress. Trainees in basic research will be required to take all or part of the Integrative Biomedical Sciences Program (Director: Lincoln), which provides organ and cell based basic science training necessary for transition from methods driven molecular biology and genetics analyses into clinically relevant, problem based studies. The K30 Translational Research Program (PI: Moreland) provides clinical investigators with the intellectual and administrative skills essential for the design and accomplishment of informative clinical studies and trials, together with a background in state of the art basic science knowledge. Funding is requested for three predoctoral and three postdoctoral trainees. Predoctoral trainees will be enrolled in the IBS, Biomedical Engineering, Cell and Molecular Biology, or M.D./Ph.D. Graduate Programs at UAB.