Cooperation among subcortical networks underlying memory

描述（由申请人提供）：海马体在记忆中的作用是 以及皮层下结构连接的重要性， 自从Korsakoff和Wernicke的开创性工作以来，海马体就被人们所知。 虽然某些记忆缺陷在一个框架中得到了最好的描述， 间脑-小脑综合征，几乎没有什么是知道这些如何 前脑系统相互作用，以及它们的相互作用是如何 由脑干组织，以便解释强大的状态依赖 学习和记忆的潜在变化。 该项目的中心焦点是海马的皮层下调节 功能，并遵循一般假设，这一作用 调节不仅是在θ和θ之间切换海马脑电图， 非theta模式，而且还可以在几个 大脑边缘系统结构与θ节律同步。海马外的 最近在许多结构中描述了θ活动， 尿烷麻醉，但从未在自然条件下。拟议研究 将测试的假设，（1）脑干/间脑系统，此外， theta和非theta之间的转换参与行为相关的罚款 在自然theta状态下调节海马活动;（2）theta节律 活动在不同边缘系统之间的神经元合作中起作用 结构和脑干结构表现出θ节律活动 专门调节这种交通;（3）θ节律活动产生于 隔和乳头复合体对神经元的活动产生反馈调节作用， 脑干核团参与大脑状态调节。 神经元活动的相位和节律同步对于神经元的活动是至关重要的。 大脑中空间分离结构的协同作用。Theta 同步性为研究这种合作提供了一个很好的模型， 它在特定的行为状态下是不同的。我们的实验需要 清醒探索和睡眠的优势作为一个自然的实验， 告诉我们记忆建立过程的组成部分。之时效 这项工作的重点是最近高涨的兴趣和数据链接 睡眠，海马活动和连续的信息处理阶段， 非REM睡眠和REM睡眠

DESCRIPTION (provided by the applicant): The role of hippocampus in memory is well established and the importance of subcortical structures connected to the hippocampus has been known since the pioneering work of Korsakoff and Wernicke. Although certain memory deficits are best described in the frameworks of a diencephalo-hippocanipal syndrome, virtually nothing is known about how these forebrain systems interact with each other and how their interaction is organized by the brainstem so as to account for the robust state dependent changes underlying learning and memory. The central focus of this project is the subcortical regulation of hippocampal function and is guided by the general hypothesis that the role of this regulation is not only to switch the hippocampal EEG between theta and non-theta patterns but also to build dynamic associations between several limbic structures that are synchronized by the theta rhythm. Extrahippocampal theta activity has been recently described in a number of structures under urethane anesthesia but never under natural conditions. The proposed research will test the hypotheses that (1) brainstem/diencephalic systems, in addition to switching between theta and non-theta take part in behaviorally-related fine tuning of hippocampal activity during natural theta states; (2) theta rhythmic activity plays a role in neuronal cooperation between different limbic structures and brainstem structures exhibiting theta rhythmic activity specifically regulate this traffic; (3) theta rhythmic activity generated in the septum and the mammillaiy complex exerts feedback regulatory influence on brainstem nuclei involved in brain state regulation. Phasic and rhythmic synchronization of neuronal activity is critical to the concerted action of spatially separated structures in the brain. Theta synchrony provides an excellent model to study such cooperation and the way in which it differs in specific behavioral states. Our experiments will take advantage of waking exploration and sleep as a natural experiment trying to inform us about the components of the memory building process. The timeliness of this work is underlined by the recent upsurge of interest and data linking sleep, hippocampal activity and successive phases of information processing in non-REM and REM sleep.