Genetic Mechanisms of Cardiac Disease in the Young

D.Woodrow Benson医学博士是一位儿科心脏病专家，长期致力于以患者为中心的研究。1995年，他在哈佛医学院塞德曼实验室接受了为期31个月的博士后研究员培训，成为一名人类分子遗传学家。1998年1月，他被南卡罗来纳医科大学录取，负责心血管遗传学的研究。他的长期研究目标是确定年轻人心血管疾病的分子基础；这项由NIH/NHLBI P50 HL61006资助的提案旨在识别其突变导致先天性心脏缺陷的基因。这项研究的目的是基于初步数据所证明的理论基础和可行性而制定的。拟议的计划将为希望从事临床研究事业的博士后学生和医学博士或博士后实习生提供以患者为导向的研究指导。指导计划可以在确定后容纳合适的初级教员。机构环境丰富，心血管研究，博士后和博士后水平的培训计划是实质性的。南卡罗来纳州儿童心脏中心有一个完善的以患者为导向的研究计划。有慷慨的机构支持来建立先天性心脏病的分子遗传学项目。所有要素都已组装起来，以建立一个丰富的环境，指导年轻心血管疾病的分子遗传学临床研究人员。获得以患者为中心的研究生涯中期奖将使本森博士能够将50%的精力投入到研究和指导临床研究人员上。

D. Woodrow Benson, M.D., Ph.D. is a pediatric cardiologist with a career long commitment to patient-oriented research. In 1995 he retrained as a human molecular geneticist during a 31 month long post- doctoral fellowship in the Seidman Laboratory, Harvard Medical School. He was recruited to the Medical University of South Carolina in January, 1998 to establish a program in cardiovascular genetics. His long-term research objective is to determine the molecular basis of cardiovascular disease in the young; this proposal, funded by NIH/NHLBI P50 HL61006 seeks to identify genes whose mutations cause congenital heart defects. The aims of the research have been developed based upon the rationale and feasibility demonstrated in preliminary data. The proposed program will provide mentoring in patient-oriented research for predoctoral students and M.D. or Ph.D. postdoctoral trainees who wish to pursue careers in clinical research. The mentoring program cart accommodate .suitable junior faculty when identified. The institutional environment is rich in cardiovascular research and the pre- and postdoctoral level training programs are substantial. A well established patient-oriented research program exists in the South Carolina Children's Heart Center. There is generous institutional support to establish a program for molecular genetics of congenital heart disease. All elements have been assembled for building an enriched environment for mentoring clinical investigators in molecular genetics of cardiovascular disease in the young. Receipt of the Mid-Career Award in patient- oriented research will allow Dr. Benson to devote 50% effort to research and mentoring clinical investigators.