CORE--BIOSTATISTICS

行政和生物统计学核心将：通过提供一个支持性的学术环境，促进脑血管疾病的高质量合作研究，使研究人员能够开展科学项目，促进项目和核心的互动，监督知识的行政和财务方面，以了解脑血管疾病的机制和管理。卒中项目中生物统计学核心的作用是支持基于临床和实验室的研究。这包括高水平的数据管理，与研究人员合作设计和进行研究，统计建模，假设制定和数据分析。有四项主要活动：1）在试点临床试验的计划、实施、分析和报告方面进行咨询和合作; 2）与研究人员进行咨询和合作，开发基于MRI的模型，以分期缺血组织，并将MRI测量结果整合到血小板聚集抑制剂治疗干预和rtPA溶栓治疗的评价中; 3）基于定量水平的存在/不存在，评估风险因素和MRI生物标志物的预后意义，以识别无应答受试者，4）协调项目实施，负责数据管理和数据质量。

The Administrative and Biostatistics Core will: promote high quality collaborative research in cerebral vascular disease by providing a supportive academic environment in which investigators can carry out scientific projects, facilitate the interaction of projects and cores, oversee the administration and financial aspects of the knowledge towards an understanding of the mechanisms and management of cerebrovascular disease. The role of the Biostatistics Core in the Stroke Project is to support the clinical and laboratory based research. This includes a high-level data management, collaboration with investigators in the design and conduct of research studies, statistical modeling, hypothesis formulation and data analyses. There are four major activities: 1) consultation and collaboration in the planning, conduct, analysis and reporting of the pilot clinical trial; 2) consultation and collaboration with research investigators in developing an MRI based model to stage ischemic tissue and to integrate MRI measurements into the evaluation of therapeutic intervention with a platelet aggregation inhibitor and thrombolysis with rtPA; 3) evaluation of the prognostic significance of risk factors and MRI biological markers, based on the presence/absence of quantitative levels to identify non-response subjects, 4) coordination on project conduct, responsibility for data management and data quality.