Smart Manganese-based Dual-Modal PET/MRI Probes

本项目旨在探索利用52Mn和51Mn PET成像来量化智能MRI造影剂的生物分布。一系列已知的和新型的螯合配体将被用于与锰中心结合，理想地稳定Mn2+氧化态，以获得最大的弛豫度和MR对比度。了解智能磁共振造影剂的作用和位置对于早期疾病检测和诊断以及细胞跟踪至关重要。随后对造影剂进行PET标记，可以了解信号的变化是由于造影剂弛豫度的变化，还是由于造影剂存在量的变化。该项目完全属于CDT的职权范围，即开发新的工具来调查和成像重要的生物医学现象，以及提供全面的化学、生物学、核磁共振成像和放射化学培训。

This project aims to explore the use of 52Mn and 51Mn PET imaging to quantify biodistribution of smart MRI contrast agents. A range of known and novel chelate ligands will be utilised to bind to manganese centres, ideally stabilising the Mn2+ oxidation state for maximum relaxivity and MR contrast. Knowledge of the action and location of smart MR contrast agents is crucial for early disease detection and diagnosis, alongside cell tracking. Subsequent PET labelling of the agents allows an understanding of whether a change of signal is due to a change of relaxivity of the contrast agent, or a change in the amount of contrast agent present.The project falls squarely within the remit of the CDT, namely by developing novel tools to investigate and image important biomedical phenomena, as well as providing comprehensive chemistry, biology, MR imaging and radiochemistry training.