MOLECULAR PHARMACOLOGY AND THERAPEUTICS

描述：分子药理学和治疗计划旨在 构思、设计和合成用于癌症和病毒患者的新药物 疾病，阐明它们的作用、抵抗和支持的机制 使用这些药物进行的临床前研究，为翻译 临床试验。该项目现已由约瑟夫·贝尔蒂诺博士领导 十年，包括31名实验室负责人和51名调查人员(包括5名 新招募的研究人员)，以及来自美国国立卫生研究院或美国国家卫生研究院的36笔赠款。它的 会员与天然产物化学等基础研究领域互动， 分子治疗学、受体生物学、细胞信号和转录 调节以及临床药理学，包括神经药理学， 细胞因子治疗和肿瘤检测。额外的16次培训或职业生涯 发展奖(K01、K05、K07、F32)由本计划成员举办。 领导层由贝尔蒂诺博士和一个执行委员会组成。正在研究-- 在每周会议和每两周一次的研讨会上介绍进展情况， 周刊俱乐部，每月一次的药物开发会议，形成一个渠道 用于将实验室研究转化为临床环境。委员会成员 参加重大疾病的跨学科小组会议。 区域。与康奈尔大学系进一步互动 药理学，包括一年一度的周末联合静修。贝尔蒂诺博士 以以下身份参与战略规划和新教师招聘 医学部的一位高级领导。这个程序利用了许多 核心设施的一部分。

Description: The Molecular Pharmacology and Therapeutics Program aims to conceive, design and synthesize new agents for patients with cancer and viral diseases, elucidate their mechanisms of action and resistance, and support preclinical research with these agents in preparation for translational clinical trials. This program has now been headed by Dr. Joseph Bertino for a decade, and encompasses 31 laboratory heads and 51 investigators (including 5 newly recruited investigators), and 36 grants from the NIH or ACS. Its members interact with such basic research areas as natural products chemistry, molecular therapeutics, receptor biology, cell signaling, and transcriptional regulation as well as clinical pharmacology, including neuropharmacology, cytokine therapy and tumor assays. An additional 16 training or career development awards (K01, K05, K07, F32) are held by members of this program. The leadership consists of Dr. Bertino and an executive committee. Researchin- progress is presented at weekly meetings as well as biweekly seminars, weekly journal club, and a monthly drug development meeting, forming a conduit for translation of laboratory research to clinical settings. Members of the program also attend the interdisciplinary group meetings for the major disease areas. Further interaction takes place with the Cornell University Department of Pharmacology, including a joint annual weekend retreat. Dr. Bertino participates in strategic planning and new faculty recruitment in his role as a senior leader in the Department of Medicine. This program makes use of many of the core facilities.