MSKCC CENTER FOR IN VIVO MOLECULAR IMAGING IN CANCER

描述：（申请人的描述） 随着对细胞和生物过程更好的理解， 分子水平与新生物试剂的开发相结合， 探针，以及成像技术的最新发展和改进， 我们应该集中精力把这些进步结合起来。 更 重要的是，人们认识到，基于分子和细胞的成像可以影响 直接用于癌症治疗和诊断， 基于分子的新疗法的测试将大大受益于 我们对特定分子和细胞过程成像能力的进步。 在 在过去的几年里，这个国家的几个团体（包括几个在 MSKCC）已经开始整合这些不同的学科，并取得了一些成功。 例如，MSKCC的多学科互动导致了 证明体内转基因表达成像的可行性，以及 非侵入性“报告基因”成像的使用正在扩大到包括 在分子水平上的特定细胞过程。 这个主题，翻译和 将基于分子和细胞的成像应用到临床竞技场， 一个MSKCC计划和这个建议的优势，这个主题是进行 在本提案的整个结构和各个组成部分中， 通过现有学科的相互作用， MSKCC：1）开发非侵入性成像范例，反映特定的 细胞/分子过程（如内源性基因表达）， 特定信号转导通路内的蛋白质-蛋白质相互作用; 2） 成像治疗基因的选择性扩增; 3）监测 基因修饰的T细胞的运输和靶向; 4）成像 体内肿瘤球体的生长和血管化; 5）使用NMR 光谱和PET成像，以优化化疗和基因治疗; 6） 在分子和细胞水平上成像安卡霉素的抗肿瘤作用 7）代谢PET显像和分子病理学在 前列腺疾病进展和反应的评估 癌症; 8）结合剂量学估计和分子靶向成像 与患者中的86 Y/90 Y标记的抗CD 19和抗CD 2 O抗体进行比较。 该提案的协调主题是分子和 基于细胞的成像对治疗和诊断有直接影响， 癌症，并提供新的研究机会，将进一步我们的 了解癌症、癌症进展和对靶向治疗的反应 到特定的分子过程。

DESCRIPTION: (Applicant's Description) With the advent of a better understanding of cell and biological processes at a molecular level coupled with the development of new biological reagents and probes, and recent developments and improvements in imaging technology, it is appropriate to focus attention on bringing together these advances. More importantly, it is recognized that molecular and cell-based imaging can impact directly on cancer treatment and diagnosis, and that the development and testing of new molecular-based therapies would benefit substantially from advances in our ability to image specific molecular and cell processes. In the last few years, several groups in this country (including several at MSKCC) have begun to integrate these diverse disciplines with some success. For example, multi-disciplinary interactions at MSKCC has led to the demonstration of the feasibility for imaging transgene expression in vivo, and the use of noninvasive "reporter gene" imaging is being expanded to include specific cell processes at a molecular level. This theme, the translation and implementation of molecular and cell-based imaging into the clinical arena, is a strength of the MSKCC program and this proposal, and this theme is carried throughout the structure and individual components of this proposal The vision of this proposal through the interaction of existing disciplines at MSKCC, is: 1) to develop noninvasive imaging paradigms that reflect specific cellular/molecular processes (such as endogenous gene expression) and protein-protein interactions within specific signal transduction pathways; 2) imaging the selective amplification of therapeutic genes; 3) monitoring the trafficking and targeting of genetically modified T cells; 4) imaging the growth and vascularization of tumor spheroids in vivo; 5) the use NMR spectroscopy and PET imaging to optimize chemotherapy and gene therapy; 6) imaging the anti-tumor effects of ancamycins ins at a molecular and cellular level; 7) the application of metabolic PET imaging and molecular-pathology in the assessment of disease progression anc response in patients with prostate cancer; 8) combining dosimetiry estimates and imaging of molecular targetins with 86Y/90Y- labeled anti-CD 19 and anti-CD2O antibodies in patients. The coordinating theme of this proposal is the potential for molecular and cell-based imaging to have a direct impact on the treatment and diagnosis of cancer, and to provide new research opportunities that will further our inderstanding of cancer, cancer progression and response to therapies targeted to specific molecular processes.