BONE MINERAL DENSITY AS A PREDICTOR OF PERIODONTITIS

描述（由申请人提供）：本研究的总体目的是 确定口腔和全身骨矿物质密度（BMD）在 绝经后妇女发生新的和进行性牙周病。 我们假设低骨密度将与新的和进行性的 牙周炎随着时间的推移，增加了对破坏性 牙周炎我们提出了一个纵向评估骨密度及其作用， 绝经后妇女牙周病的建立 使用灵敏和准确的骨骼和口腔BMD测量方法的研究，以及 牙周病作为BMD评估的一部分，我们将进一步验证 口腔BMD的方法学。与此同时，评估了各种 低骨密度和牙周炎的潜在共同危险因素将使我们能够 确定他们对这个协会的贡献。系统协变量 包括年龄、体重指数、吸烟、饮酒、激素使用、社会经济 心理社会因素、药物、病史和生殖史以及饮食。 局部协变量包括牙菌斑、牙龈炎、探诊深度、先前的牙科治疗、 护理和牙齿护理习惯。研究受试者将从 已建立的绝经后女性队列，具有BMD基线评估， 牙周炎作为一个正在进行的横断面研究的一部分。我们建议3-vear 对1000名已入组NIH的绝经后妇女进行随访检查 妇女健康倡议研究。到目前为止，研究还没有确定 骨及下颌骨骨密度在牙周病中特殊作用 绝经后妇女大队列中的发病率和进展。我们 初步的横断面研究已经确定， 与牙槽嵴高度、牙齿缺失和临床附着相关 损失拟议的纵向研究将有足够的样本量， 评估BMD和BMD之间时间关系的统计功效 牙周炎的影响和一个大的一套共同危险因素和潜在的 影响骨质减少、牙周病或两者的混杂因素。这 研究提供了一个独特的机会，以确定这种关系的成本 作为研究的一部分， 妇女健康倡议具有重大的现实意义。低BMD是 可能在发病和进展中具有相当重要的意义， 牙周炎因此，一旦建立了关系， 在预防和治疗骨质疏松症可能被证明是有用的预防 以及治疗牙周炎和随后的牙齿脱落。

DESCRIPTION (provided by applicant): The overall purpose of this study is to determine the role of oral and systemic bone mineral density (BMD) in the development of new and progressive periodontal disease in postmenopausal women. We hypothesize that low BMD will be associated with both new and progressive periodontitis over time by increasing susceptibility to destructive periodontitis. We propose a longitudinal assessment of BMD and its role in establishment of periodontal disease in postmenopausal women with systematic studies using sensitive and accurate measures of skeletal and oral BMD, and periodontal disease. As part of the BMD assessment, we will further validate the methodology for oral BMD. In concert with these, assessment of a variety of potential co-risk factors for both low BMD and periodontitis will allow us to determine their contribution to this association. The systemic covariates include age, body mass index, smoking, alcohol, hormone use, socioeconomic and psychosocial factors, medications, medical and reproductive history, and diet. Local covariates include plaque, gingivitis, probing depth, previous dental care, and dental care habits. Study subjects will be recruited from an established cohort of postmenopausal women with baseline assessments of BMD and periodontitis as part of an ongoing cross-sectional study. We propose a 3-vear follow-up examination in 1000 postmenopausal women already enrolled in the NIH Women's Health Initiative study. To date, studies have not characterized the specific role of BMD either skeletal or mandibular on periodontal disease incidence and progression in a large cohort of postmenopausal women. Our preliminary cross-sectional studies have determined that skeletal BMD is associated with alveolar crestal height, tooth loss and clinical attachment loss. The proposed longitudinal study will have sufficient sample size and statistical power to assess the temporal relationship between BMD and periodontitis and the effects of a large set of co-risk factors and potential confounding factors affecting osteopenia, periodontal disease or both. This study provides a unique opportunity to define this relationship in a cost effective manner in a cohort of postmenopausal women under study as part of the Women's Health Initiative and has great practical significance. Low BMD is likely of considerable importance in the onset and progression of periodontitis. Hence once the relationship is established, modalities effective in the prevention and treatment of osteoporosis may prove useful for prevention and treatment of periodontitis and subsequent tooth loss.