STANFORD ALZHEIMER'S DISEASE CORE CENTER

这一申请反映了斯坦福大学对阿尔茨海默病（AD）研究的持续承诺。自从13年前国家精神卫生研究所（NIMH）的老年人精神病理学研究项目成立以来，我们就有了一个专注于阿尔茨海默病研究的NIMH中心。类似于AIA“阿尔茨海默病核心中心（ADCC）”的结构，我们的NIMH中心专注于AD的研究。与NIA的“阿尔茨海默病核心中心（ADCC）”类似，NIMH中心的结构是一个“授权或核心中心”，旨在利用“核心资源”促进阿尔茨海默病独立资助研究的发展。我们觉得我们在这方面的努力是成功的，利用中心的核心在斯坦福进行了资助的广告项目。我们未来的计划是作为一个ADCC继续沿着这条轨道前进，因为我们中心的目标和结构与NIA项目的任务更一致，而不是与不再支持“核心中心”的新NIMH项目相一致。鉴于我们作为一个拥有既定核心的授权中心的历史记录，我们觉得我们非常适合完成这一过渡。我们中心的主要重点是研究AD异质性的各个方面。在目前的申请中，我们已经扩大了我们提议的ADCC的重点，以促进三个主要领域的研究：病因学；疾病进展；以及AD相关行为症状的病理生理学这项工作将与该大学在基础神经科学和遗传学、神经成像和睡眠/时间生物学方面的主要研究项目紧密结合。我们的期望是，我们不仅将促进这三个单独领域的研究，而且由于我们的跨学科经验，我们将促进研究工作，桥梁学科和增加思想的交流。我们认为这种多因素和跨学科的方法可能最好地解决当前AD研究的复杂问题。

This application reflects the continuing commitment of Stanford University to the study of Alzheimer's Disease (AD). Since the inception of the National Institute of Mental Health (NIMH) program for the Study of Psychopathology in the Elderly over 13 years ago, we have had an NIMH Center focusing on the study of AD. Similar to the AIA "Alzheimer's Disease Core Center (ADCC)," the structure of our NIMH Center focusing on the study of AD. Similar to the NIA "Alzheimer's Disease Core Centers (ADCC), the structure of NIMH Center has been that of an "enabling or core center" designed to use "core resources" to facilitate the development of independently funded research on AD. We feel that we been successful in this endeavor, producing funded AD projects at Stanford using the Center's core. Our plan for the future is to continue along this track as an ADCC because the objectives and structure of our Center our Center are more consistent with the mandate of the NIA program than with new NIMH programs that will no long support "core centers" Given our log history as an enabling center with established cores, we feel that we are ideally suited to accomplish this transition. The primary focus of our Center has been the study of aspects for the heterogeneity of AD. In the current application we have expanded the focus of our proposed ADCC to facilitate research in three major areas: etiology; progression of disease; and pathophysiology of associated behavioral symptoms in AD. This work will be closely integrated with major research programs at the University in basic neurosciences and genetics, neuroimaging, and sleep/chronobiology. Our expectation is that we will not only facilitate research in these three individual areas but also, because of our interdisciplinary experience, we will foster research efforts that bridge disciplines and increase cross-fertilization of ideas. We feel that this multi-factorial and interdisciplinary approach may best address complex questions current to AD research.