PHOTORECEPTOR FUNCTION IN RETINOPATHY OF PREMATURITY

描述（申请人的描述）：光感受器的新证据 参与之前和之后的决议的活动，血管阶段， 早产儿视网膜病变（ROP）导致本项目的主要假设： 光感受器功能的缺陷越大， ROP阶段。婴儿（10周龄时入组）和儿童（8-12岁时入组 根据ROP的严重程度（无、轻度、中度、重度）分类， 视网膜电图（ERG）和感光器的心理物理学研究 功能在所有受试者中， 光转导和暗适应杆阈值将在 视网膜旁和周边视网膜。将分析棒响应参数， 与ROP类别有显著差异。视网膜机制表现在后 受体反应，以及受体与受体后的关系 功能也将被分析。ROP中的高屈光不正经常 在光感受器成熟的年份中发育。在这个项目中， 视网膜机制，次要假设是：感光细胞越大， 功能障碍者屈光不正越大。所有受试者将 测量睫状肌麻痹屈光度和视力。评价 为因果关系发展视网膜突起和等效球镜， 不同年龄组视杆细胞阈值、视敏度和屈光不正的纵向研究 将进行10周和3年。这些课程的参数，以及 视网膜反应参数在其他研究中获得的视网膜 函数，将用于检验次要假设。在儿童，其他 光感受器功能包括杆光转导的失活， 视锥细胞光转导的激活和视杆细胞增加阈值功能 将进行调查。获得的参数将用于进一步的测试， 主要假设和次要假设，以及受试者内评价 视杆细胞与视锥细胞的相对参与，激活与失活，以及 受体机制与受体后机制。这个项目完全基于 ROP的新视角，不仅会带来更多关于 视网膜和视功能的ROP，而且还对新的知识有关的基础 ROP疾病过程。

DESCRIPTION (Applicant's Description): New evidence for photoreceptor involvement before and after resolution of the active, vascular phase of retinopathy of prematurity (ROP) leads to the main hypothesis of this project: the greater the deficit in photoreceptor function the more severe the acute phase ROP. Infants (enrolled at age 10 wks) and children (enrolled at age 8-12 yrs) categorized by severity of ROP (None, Mild Moderate, Severe) will have electroretinographic (ERG) and psychophysical investigations of photoreceptor function. In all subjects, the parameters of the activation of rod phototransduction, and dark-adapted rod thresholds will be measured in parafoveal and peripheral retina. Rod response parameters will be analyzed for significant variation with ROP category. Retinal mechanisms represented in post receptoral responses, and the relationship of receptoral to post-receptoral functions, will also be analyzed. High refractive errors in ROP frequently develop during the years when photoreceptors mature. In this project about retinal mechanisms, the secondary hypothesis is: the greater the photoreceptor dysfunction, the greater the refractive error. All subjects will have cycloplegic refractions, as well as acuities, measured. To evaluate the developing retinal processes and spherical equivalent for causative relations, a longitudinal study of rod thresholds, acuity and refractive error between age 10 wks and 3 yrs will be conducted. The parameters of these courses, as well as the retinal response parameters obtained in the other studies of retinal function, will be used to test the secondary hypothesis. In the children, other photoreceptor functions including deactivation of rod phototransduction, activation of cone phototransduction, and rod increment threshold functions will be investigated. The parameters obtained will be used in further tests of the main and secondary hypotheses, and for within subject evaluation of relative involvement of rods vs. cones, activation vs. deactivation, and receptoral vs. post-receptoral mechanisms. This project, based on an entirely new perspective of ROP, will lead not only to much more information about retinal and visual function in ROP, but also to new knowledge about fundamental ROP disease processes.