Developing the next generation of Collagen Membranes using Electrophoretic Deposition

一种新的胶原膜技术已经被开发出来，它有可能带来一系列的好处，包括能够制造比目前可用的更大的胶原膜，其中膜可以制成任何所需的厚度和采用任何所需的形状。膜是耐缝线拔出，并能维持活细胞再生应用。传统的膜制造方法使用脱细胞的动物组织，这限制了它们的大小，要求外科医生使用多个膜，并且阻止它们用于大面积伤口，如烧伤或糖尿病溃疡。此外，脱细胞过程可能会破坏膜的结构，或无法清除动物的所有痕迹，导致炎症和排斥反应。这项新技术使用了一种改进的电泳沉积技术，可以快速制造和精确控制一系列重要的膜参数，包括尺寸、厚度和形状。这是通过利用电场操纵悬浮液中生物分子固有的带电性质来实现的。该技术可用于制造各种针对特定临床需求的膜，并可制造复杂和有针对性的产品。本项目旨在进一步拓展这一研究，开发具有广泛应用前景的新型胶原膜技术。

A new collagen membrane technology has been developed which has the potential to allow for a range of benefits, including the ability to make much larger collagen membranes than those currently available, where membranes can be made to any desired thickness and adopt any desired shape. The membranes are resistant to suture pull-out and can sustain live cells for regenerative applications.Conventional membrane fabrication methods use decellularised animal tissue which limits their size, requiring surgeons to use multiple membranes and preventing their use in larger area wounds such as burns or diabetic ulcers. Additionally, the decellularisation process can damage the structure of the membrane, or fail to remove all traces of the animal, leading to inflammation and rejection. The new technology uses a modified electrophoretic deposition technique to allow for rapid fabrication and precise control over a range of important membrane parameters including the size, thickness and shape. This is achieved by manipulating the inherently charged nature of biomolecules in suspension using electric fields. This technique can be applied to fabricate a wide variety of membranes tailored towards specific clinical needs and can create complex and targeted products. This project aims to expand on this research and develop the new collagen membrane technology with a wide range of applications.