Biomedical Research at the University of Guam: Equipment

描述（由申请人提供）：拟议的关岛大学SCORE计划的具体目的是为教师提供机会，利用关岛大学的研究设施进行生物医学上重要的研究，从而提高整体研究环境。UOG SCORE项目有四个目标：1)增加关岛大学教师进行尖端生物医学研究的现场能力；2)增加UOG教师到研究密集型机构进行非现场生物医学研究的机会；3)改善UOG在生物医学研究质量、能力和生产力方面的研究氛围；4)加强研究与教与学之间的联系，使学生能够从加强的研究活动中受益，并从他们独特的文化观点中为学院的生物医学研究工作贡献有价值的观点。该计划目前包括四个研究项目。其中两个项目侧重于海洋生物医学研究，并将利用关岛生物多样化的热带海洋环境。研究项目包括：1)珊瑚生殖生物学和遗传学研究；2)珊瑚礁大型藻类和海绵生物医学活性天然产物的化学变异；3)在人类肿瘤发生中发挥作用的新型调控转录延伸因子；4)氢原子提取反应中氨基基和巯基自由基的反应活性。在这个拟议的设备补充中，SCORE教员已经确定了关键设备需求，这将促进所有四个研究项目。要求提供高性能液相色谱（HPLC）仪器，为这些研究项目提供更强的分析专业知识，并要求冷冻干燥机用于海洋样品的基本制备和保存。

DESCRIPTION (provided by applicant): The specific aim of the proposed University of Guam SCORE program is to provide opportunities for the faculty to conduct biomedically significant research utilizing the research facilities of the University of Guam, thus enhancing the overall research environment. The UOG SCORE program has four goals: 1) Increase the on-site capacity of University of Guam faculty to do cutting-edge biomedical research; 2) Increase the opportunities for UOG faculty to do biomedical research off-site at research-intensive institutions; 3) Improve the research climate at UOG, in the areas of quality, capacity, and productivity, for biomedical research; and 4) Strengthen the link between research and teaching and learning so that students can benefit from the enhanced research activities and can contribute valuable perspectives from their unique cultural views to the faculty's biomedical research endeavors. The program currently includes four research projects. Two of the projects focus on marine biomedical research and will utilize the biologically diverse tropical marine environment of Guam. Research projects include 1) studies of reproductive biology and genetics of corals, 2) chemical variation in biomedically active natural products in coral-reef macroalgae and sponges, 3) novel regulatory transcription elongation factors that play a role in human tumorigenesis, and 4) the reactivity of aminyl and thiyl radicals in hydrogen atom abstraction reactions. In this proposed equipment supplement, the SCORE faculty members have identified key equipment needs that will facilitate all four of the research projects. High performance liquid chromatography (HPLC) instrumentation is requested that will provide enhanced analytical expertise for these research projects, and a freeze dryer is requested for basic preparation and preservation of marine samples.