2003 Conference on Implantable Auditory Prostheses

描述(申请人提供)：人工耳蜗是第一个获得广泛临床应用所必需的技术成功的神经假体。它为恢复重度聋人的声音感觉和言语理解提供了唯一有效的治疗方法。在过去的20年里，患者使用这些设备的表现已经取得了戏剧性的改善。目前，植入人工耳机的成年人的平均语音理解得分在80%-100%之间。这些进展在很大程度上源于广泛科学学科的研究人员的集体努力。这种密切的合作和合作在很大程度上是通过一系列两年一次的研究会议来促进的，这些会议始于1983年戈登可植入听觉假体研究会议。这些会议是唯一一个将植入研究问题作为唯一焦点的论坛。自上次(2001年)会议以来的一个新进展是，有可能将电刺激与其他营养物质结合起来，以确保减少神经元件的退化。这一进展将在2003年的会议上详细讨论，并将包括来自实验动物的体外和体内数据，以及临床上拟议的神经营养素输送的概述。会议还将重点讨论本次会议的一个核心主题--改进信号处理方面的新进展。本课程将批判性地研究随机共振在信号处理方案中的应用，并根据我们对正常耳蜗处理过程的理解，研究采用方案的可能性。除了这些主题外，我们还将考察以下方面的最新研究：(1)剥夺和刺激对听觉系统可塑性的影响，(2)声(低频)和电(高频)联合听力，(3)人工耳蜗电生理监测，(4)新型人工耳蜗电极阵列，(5)人工耳蜗术心理物理学，(6)双耳人工耳蜗术，以及(7)耳蜗术相关领域专家的“超越视野”讲座。总而言之，会议将延续综合来自多个学科的信息的传统，以努力更好地了解耳蜗电刺激，并改善安装了人工耳蜗的患者的表现。本申请寻求对定于2003年8月17日至22日在加利福尼亚州太平洋格罗夫的Asilomar会议中心举行的这次会议的部分支持。

DESCRIPTION (provided by applicant): The cochlear implant is the first neural prosthesis to achieve the technical success necessary for widespread clinical application. It provides the only effective therapy for restoring sound sensation and speech understanding to the profoundly deaf. Over the past 20 years, dramatic improvements in patients' performance with these devices have been achieved. Currently the average speech understanding score for implanted adults is between 80-100% correct. These advances have derived substantially from the collective efforts of researchers in a broad array of scientific disciplines. This close collaboration and cooperation has been fostered in large part through a series of biennial research conferences, originating with the 1983 Gordon Research Conference on Implantable Auditory Prostheses. These conferences are the only forum in which implant research issues are the sole focus. A 'new' development since the last (2001) meeting is the potential to combine electrical stimulation with other trophic agents to ensure reduced degeneration of neural elements. This development will be discussed at length in the 2003 meeting, and will include both in vitro and in vivo data from experimental animals, together with an overview of the proposed delivery of neurotrophins clinically. The meeting will also focus on new developments in a core theme of this meeting - improved signal processing. This session will critically examine the application of stochastic resonance in signal processing schemes, and examine the potential to employ schemes based on our understanding of processing in the normal cochlea. In addition to these topics we will examine the latest research on (1) the effects of deprivation and stimulation on plasticity of the auditory system, (2) combined acoustic (low frequency) and electric (high frequency) hearing, (3) electrophysiological monitoring in cochlear implants, (4) new innovative electrode arrays for cochlear implants, (5) implant psychophysics, (6) binaural cochlear implants, and (7) "beyond the horizons" talks by experts in fields related to cochlea implants. In sum, the conference will continue the tradition of combining information from a wide range of disciplines in an effort to better understand electrical stimulation of the cochlea and to improve the performance of patients fitted with cochlear implants. This application seeks partial support for this conference, scheduled at the Asilomar Conference Center, Pacific Grove, CA on August 17-22, 2003.