Reactive Intermediates: The Vanguard

描述（由申请人提供）：本申请寻求对将于2003年9月8日至10日在纽约市举行的美国化学学会第226次会议上举行的为期半天的研讨会的支持，该研讨会由化学毒理学部赞助。 研讨会的标题是：“反应性中间体：先锋”，并寻求专注于最新的新化学有关的化学损害人类健康。 当然，包括癌症在内的许多疾病的复杂病因是由对生物分子的化学损伤引起的;脂质，蛋白质和DNA。 在过去的三十年里，在确定环境和内源性各种来源的损害类型方面取得了相当大的进展。 虽然在某些特定情况下，已经出现了基本化学事件的相当简单的画面，但越来越明显的是，最终构成可能影响疾病的损害的化学复杂性相当大。 最初的或主要的损害事实上可能演变成一系列的次要损害事件。 这些次要事件可能最终导致、加剧或以其他方式调节“起始”事件。 初始事件和次级事件均由活性中间体介导。 了解这些中间体化学的基本方面，它们的结构，反应性和反应产物，对于解剖最终导致关键损害事件发展到病态状态的物种至关重要。 本次研讨会的目的是汇集领先的化学家谁是参与了解光谱的主要和次要的反应中间体和化学，引起细胞损伤，引发疾病，特别是癌症。

DESCRIPTION (provided by applicant): This application seeks support for a half-day symposium to be held at the 226th meeting of the American Chemical Society September 8-10, 2003 in New York City that is sponsored by the Division of Chemical Toxicology. The Symposium is titled: "Reactive Intermediates: The Vanguard" and seeks to focus on the latest novel chemistry relevant to chemical damage in human health. Certainly the complex etiology of many diseases, including cancers, is initiated by chemical damage to biomolecules; lipids, proteins and DNA. Over the last thirty years, considerable progress has been made in characterizing types of damage from a variety of sources both environmental and endogenous. While in some select cases, a reasonably straightforward picture of the underlying chemical events has emerged, it has become increasingly apparent that there is considerable chemical complexity in what ultimately constitutes damage that may affect disease. The initial, or primary, damage may in fact evolve in a series of subsidiary damage events. These subsidiary events may ultimately be responsible for, intensify or otherwise modulate the "initiating" event. Both the initial event and the subsidiary events are mediated by reactive intermediates. Understanding the fundamental aspects of the chemistry of these intermediates, their structure, reactivity and reaction products, is essential in dissecting the species that ultimately give rise to key damage events that devolve to the morbid state. The purpose of this symposium is to bring together leading chemists who are involved in the understanding the spectrum of primary and subsidiary reactive intermediates and the chemistry that gives rise to cellular damage that initiates disease, particularly cancer.