FASEB SUMMER RESEARCH CONFERENCE: TRANSPORT ATPASES

描述(由申请者提供)：这是一份为FASEB夏季研究会议申请部分资金的申请，主题为“运输ATPase：基因组学、机制和与疾病的相关性”。会议将于2003年7月12-17日在佛蒙特州萨克斯顿河的佛蒙特州学院举行。该会议由FASEB有关委员会审查和批准，将是每两年举行一次的关于这一主题的第四次会议。会议的主要目标是聚集约150名与会者，其中包括该领域的顶尖科学家，但也包括年轻的研究人员和博士后研究员。会议日程包括两场主题演讲，九场各4场演讲，海报观看和讨论，以及博士后论坛。讨论的主题包括：转运蛋白ATPase的基因组概况、钙离子转运蛋白的晶体结构和机制、ABC转运蛋白的晶体结构和机制、酵母系统中转运蛋白ATPase的晶体结构和机制、ATP合成酶的晶体结构和机制、比较ATPase的结构和机制、血浆Na+、K+和Ca2+ATPase的机制和调节、钙离子转运蛋白酶在心脏功能和疾病中的作用以及转运蛋白ATPase与人类疾病的相关性。除了讲座，还将有海报演示和博士后论坛，以促进更成熟和更年轻的科学家之间的交流。预计这次会议将对基础科学和医学科学都具有重要意义。晶体结构定义的惊人进步促进了对机制的理解，并为建模和药物开发开辟了途径。此外，基因组调查揭示了越来越多的与运输ATPase相关的遗传疾病。最后，很明显，常见疾病状态的致病特征，如心力衰竭和耐药性，与转运蛋白ATPase的表达和/或功能改变有关。会议涉及NHBLI(钙和Na+，K+ATPase；ABC转运体)、NIAMS(钙转运体)、NIGMS(所有转运体ATPase)、NIDDK(CFTR，铜ATPase)、NCI(MDR/P糖蛋白和MRP1)以及NEI(ABCR)的任务。参加会议的有许多知名科学家和初级科学家，有男性也有女性。

DESCRIPTION (provided by applicant): This is an application for partial funding for a FASEB summer research conference titled "Transport ATPases: Genomics, Mechanisms and Relevance to Diseases". The conference will be held in the Vermont Academy, Saxton River, Vermont, on July 12-17, 2003. The Conference was reviewed and approved by the appropriate FASEB Committee, and will be the fourth meeting held every two years on this subject. The major goal of the meeting is to bring together about 150 participants, including the top scientists in this field, but also younger investigators and postdoctoral fellows. The conference schedule include two keynote lectures, nine sessions with 4 talks each, poster viewing and discussion, and a postdoc forum. The subjects of discussion will be: Genomic survey of transport ATPases, crystal structure and mechanism of the Ca 2+ATPase, crystal structure and mechanism of the ABC transporters, transport ATPases in yeast systems, crystal structure and mechanisms of the ATP synthase, comparative ATPase structure and mechanisms, mechanism and modulation of plasma Na+,K+ and Ca 2+ATPases, Ca 2+ATPase in cardiac function and disease, and relevance of transport ATPases to human diseases. In addition to lectures, there will be poster presentations and a post-doc forum to foster communication among more established and younger scientists. It is expected that the conference will be highly significant with regard to both basic and medical sciences. The astounding progress in definition of crystal structures facilitates understanding of mechanisms and open up avenues for modeling and drug development. Furthermore, genomic surveys reveal an increasing number of genetically linked diseases of transport ATPases. Finally, it is clear that pathogenetic features of common disease states, such as heart failure and drug resistance, are related to altered expression and/or function of transport ATPases. The conference is related to the mission of the NHBLI (Ca 2+ and Na+,K+ATPase; ABC transporters), NIAMS (Ca 2+ATPases), NIGMS (all transport ATPases), NIDDK (CFTR, copper ATPase), NCI (MDR/Pglycoprotein and MRP1, and the NEI (ABCR). There is a good representation of established and junior scientists at the meeting, both male and female.