First Int'l Symposium on Childhood and Adolescent NHL

描述（由申请人提供）：我们建议组织和举办第一次（2003年4月10日至12日）和未来每隔一年举办一次儿童和青少年非霍奇金淋巴瘤（NHL）国际研讨会（c&a: NHL）。在美国，儿童和青少年NHL是一种罕见的孤儿病，每年大约只有750-800例。然而，尽管在过去的20年里，儿童（0-14岁）NHL的死亡率急剧下降（63%）（3.0/ 10.6[1979]至1.1/ 10.6[1998]），但用于提高我们对流行病学、基础生物学、新型转化和靶向治疗的开发以及这种孤儿病的长期影响的理解的资源有限。成人NHL仍然是一种罕见但更常见的疾病（55,000/年/美国），在相同的20年期间，与c&a NHL相比，死亡率只有最小的下降，过去得到了更多的NIH和生物制药教育会议的支持。尽管C和A:NHL的死亡率有所改善，但仍有许多未解决的问题需要进行重要的调查，这些问题可以在有关该主题的多学科国际专题讨论会之后部分进行。本次会议的目的包括：（简要）主要：1)介绍和讨论最近在流行病学、基础生物学、转化研究、临床调查和慢性非霍奇病和年轻成人NHL的长期影响方面的结果；2)重点介绍NHL分子表征和免疫靶向治疗的进展；3)促进青年研究者参与和领导c&a:NHL；4)弥合儿童和成人常见NHL组织学之间的科学/医学差距。次要目标：1)建立一个国际公认的C & A:NHL所有组织学分期系统；2)应用病理NHL分类（REAL/WHO）， C & A:NHL；3)描述发展中国家对非霍奇金淋巴瘤的最小和标准治疗；4)促进在这一孤儿疾病的教育和研究方面的国际交流与合作。本次国际研讨会的结果可能会增加我们对这种罕见疾病的流行病学、生物学和临床结果的理解，并为年轻研究人员提供机会，促进国际研究倡议，为未来几代患有NHL的c&a患者开发毒性更小、更有针对性的分子和免疫治疗方法。

DESCRIPTION (provided by applicant): We propose to organize and conduct the first (April 10-12, 2003) and in the future every other year an International Symposium on Childhood and Adolescent Non-Hodgkin's Lymphoma (NHL) (C & A: NHL). NHL in children and adolescents is an orphan (rare) disease accounting for only approximately 750-800 cases per year in the U.S. However, despite a dramatic decline (63%) in the mortality rate of childhood (0-14 yrs) NHL in the last 20 yrs (3.0/10 6 [1979] to 1.1/10 6 [1998]), there has been limited resources applied to increasing our understanding of the epidemiology, basic biology, development of novel translational and targeted therapies and long term effects of this orphan disease. Adult NHL, a still rare but more common disease (55,000/yr/U.S.), with only a minimal decline in mortality rates compared to C & A:NHL in the same 20 yr period, has in the past received substantially more NIH and biopharmaceutical education conference support. Despite the improvement in mortality rate in C & A:NHL, there are still a number of unanswered questions which require critical investigation that could be pursued in part following a multidisciplinary international symposia on this subject matter. The objectives of this proposed conference include: (Brief) Primary: 1) presentation and discussion of recent results in the epidemiology, basic biology, translational research, clinical investigations and long-term effects of C & A and young adults with NHL; 2) highlight advances in molecular characterization and immune targeted therapies in NHL; 3) promote young investigator participation and leadership in C & A:NHL; and 4) bridge the scientific/medical gap between common NHL histologies in children and adults. Secondary objectives: 1) develop an international accepted staging system for all histologies of C & A:NHL; 2) apply pathological NHL classifications (REAL/WHO) with C & A:NHL; 3) characterize minimal and standard therapy for C & A:NHL for developing countries; and 4) facilitate international communication and collaboration in education and research in this orphan disease. The results of this proposed International Symposium will likely increase our understanding of the epidemiology, biology and clinical results of this rare disease and provide and opportunity to engage young investigators, facilitate international research initiatives and develop less toxic and more targeted molecular and immune based therapies for future generations of C & A with NHL.