Chloride Signaling

描述(由申请人提供)： 这项建议的目的是帮助支持将于2003年9月3-7日在马萨诸塞州伍兹霍尔海洋生物实验室举行的关于“氯信号”的国际研讨会。本次会议将是第57届全科生理学家学会(SGP)年会。SGP的主要目的，如果不是唯一的目的，是每年主办一次关于不同主题的研讨会。这次会议的议题特别及时和引人注目。一般来说，阴离子通道比阳离子通道受到的关注较少，部分原因是它们的功能和病理生理学不那么明显，而且现有的方法还不够强大，不足以破解它们。最近，CI通道以一种意想不到的方式在基本的生理和细胞生物学过程中扮演着非常重要的角色，这一点已经变得清晰起来。由于CI通道缺陷引起的疾病正在迅速被发现。今年发布了第一个CI渠道的晶体结构，这肯定会为CI渠道渗透提供新的和令人兴奋的见解。由于最近认识到胞内CI是动态的，可能对某些蛋白质的功能有直接作用，而且细胞内CI的调节依赖于各种其他活性的运输蛋白，所以这次研讨会被命名为“氯信号”而不是“氯通道”。希望这次研讨会将有助于确定氯化物生物学研究的重要方向。演讲者已被选为代表世界各地氯化物信号的领导人。主题的高调特征使我们对高出席率(约300人)充满信心。我们的会议宣传将鼓励来自各个职业层次的广泛科学家的参与--从探索阴离子渗透和与蛋白质结合的机制的结构生物学家，到对氯离子在膜运输中的作用感兴趣的细胞生物学家，对氯离子通道信号感兴趣的神经科学家，参与离子动态平衡的运输生理学家，以及对通道病感兴趣的遗传学家。

DESCRIPTION (provided by applicant): The aim of this proposal is to help support an international symposium on "Chloride Signaling" to be held September 3-7, 2003, at the Marine Biological Laboratory in Woods Hole, Massachusetts. This meeting will be the 57th Annual Symposium of the Society of General Physiologists (SGP). The major, if not sole, purpose of the SGP is to host a symposium each year on a different subject. The topic of this meeting is especially timely and compelling. Anion channels in general have received less attention than cation channels, partly because their functions and pathophysiology was not as evident and because the available methodology was not powerful enough to crack them. Recently it has become clear that CI channels play very important roles in fundamental physiological and cell biological processes in ways that were not anticipated. Diseases due to CI channel defects are rapidly being discovered. This year the crystal structure of the first CI channel was published, which is certain to provide new and exciting insights into CI channel permeation. The symposium is titled "Chloride Signaling" rather than "Chloride Channels" because of the recent realization that cytosolic CI is dynamic and may have direct actions on the function of some proteins and because the regulation of intracellular CI depends on a variety of other active transport proteins. The hope is that this symposium will be formative in identifying important directions for research in the biology of chloride. The speakers have been selected to represent the leaders in chloride signaling around the world. The high-profile character of the subject makes us confident of high attendance (approximately 300 participants). Our publicity for the meeting will encourage participation from a wide sweep of scientists at all career levels-from structural biologists exploring the mechanisms of anion permeation and anion binding to proteins, to cell biologists interested in the roles of chloride in membrane trafficking, neuroscientists interested in the signaling of chloride channels, transport physiologists involved in ion homeostasis, and geneticists interested in channelopathies