Gordon Conference on Synaptic Transmission

描述（由申请人提供）：突触作为基本的信号传导 神经元是神经系统的一个单位，突触传递与大多数神经元有关。 神经系统疾病，以及精神疾病，药物成瘾，学习， 记忆、发育障碍、疼痛、视力和与衰老有关的痴呆。 虽然突触的概念已经伴随我们一个世纪了， 多年来，我们对突触的理解取得了前所未有的进展， 通过新的分子和生物物理技术。这些新方法有助于 重新将神经科学家的兴趣集中在电的基本主题上， 以及兴奋细胞之间的化学信号。这些新的融合 方法创造了对论坛的需求，以供之间交流想法 来自不同学科的研究人员被吸引到这个话题。的 戈登会议突触传输有助于满足这一需求。这 会议在非常成功和受欢迎的形式下举行， 戈登研究会议，这是典型的两年一度的事件。岛叶 戈登会议的设置，密切联系和轻松的气氛鼓励 研究人员之间的讨论和交流，并促进联系 演讲者和与会者之间，包括不同的学生群体， 博士后和教职员工关于Synaptic的前两次Gordon会议 传输（1998年和2000年）非常受欢迎，会议计划 至少再持续三个周期。会议分为八个部分 会议加两次全体会议。会议将涵盖的主题包括 突触前和突触后机制、视网膜传递、突触方面 电路，突触可塑性，疼痛，突触计算和翻译 research.这些会议不仅通过共同的主题， 突触，同时也通过分子生物学的尖端技术， 遗传学、膜片钳和光学成像。30位主要发言人和8位 讨论领导者将站在这些领域研究的最前沿， 将对复杂的新问题进行深入介绍。这项建议是 为2002年、2004年和2006年会议提供支助， 因为每年的会议都是类似的。2002年，全体会议 诺贝尔奖获得者伯特·萨克曼和伊芙·马尔德将发表演讲。这些 讲座将为课程定下基调，课程旨在探索 突触传递的生物物理机制，以及 神经回路行为中突触。会议将产生一个彻底的 讨论，同时保持对突触传递的明确关注。

DESCRIPTION (provided by applicant): The synapse serves as the basic signaling unit of the nervous system, and synaptic transmission is relevant to most neurological diseases, as well as to mental illness, drug addiction, learning, memory, developmental disorders, pain, vision, and aging related dementias. Although the concept of the synapse has been with us for a century, recent years have seen unparalleled progress in our understanding of synapses, spawned by new molecular and biophysical technologies. These new approaches have helped to refocus the interests of neuroscientists on the basic topic of electrical and chemical signaling between excitable cells. The convergence of these new approaches has created a need for forums for the exchange of ideas between researchers from diverse disciplines that have been drawn to this topic. The Gordon Conference on Synaptic Transmission helps to fill this need. This meeting has been held under the immensely successful and popular format of Gordon Research Conferences, which are typically biyearly events. The insular setting, close contact, and relaxed atmosphere of Gordon Conferences encourage discussion and exchange of ideas between researchers, and promotes contact between speakers and attendees, including a diverse group of students, post-docs, and faculty. The first two Gordon Conferences on Synaptic Transmission (1998 and 2000) were hugely popular, and the meeting is planned to continue for at least another three cycles. The meeting is organized into eight sessions plus two plenary lectures. The sessions will cover topics that include aspects of pre- and postsynaptic mechanisms, retinal transmission, synaptic circuitry, synaptic plasticity, pain, synaptic computations, and translational research. The sessions will be connected not only through the common theme of the synapse, but also through the cutting edge techniques of molecular biology, genetics, patch clamping, and optical Imaging. The 30 principal speakers and 8 discussion leaders will be at the forefront of research in these fields, and will give in-depth presentations on complex emerging issues. This proposal is for support for the meeting in years 2002, 2004, and 2006, and the basic format for the meeting will be similar for each of those years. In 2002, the plenary lectures will be given by Nobel Laureate Bert Sakmann and Eve Marder. These lectures will set the tone for the sessions, which are designed to explore both the biophysical mechanisms of synaptic transmission, as well as the role of the synapse in neural circuit behavior. The meeting will generate a thorough discussion, while maintaining a clear focus on synaptic transmission.