Gordon Research Conference of Polyamine

多胺是小的阳离子烷基胺，对细胞生长和存活是绝对必要的。主要的天然存在的多胺，亚精胺和精胺及其二胺前体腐胺通过高度调节的代谢系统维持在高细胞内浓度。多胺的细胞内水平也部分地由高度特异性的、能量依赖性的多胺转运系统调节。多胺及其代谢途径引起了人们极大的兴趣，因为许多病理状态都伴随着多胺代谢的改变和多胺水平的增加，包括肿瘤性疾病。对多胺分子作用的理解的迅速增加导致了在开发干扰多胺代谢和功能的试剂方面的相当大的进展。这些试剂已显示出作为治疗剂和作为工具来增加对原核和真核细胞中多胺功能的理解的希望。目前提案的目的是为一年两次的多胺问题戈登会议获得部分资金。拟议的会议将为高级和初级研究人员之间自由交流信息和新想法提供一个良好的环境，这些研究人员将涵盖广泛的兴趣，包括基础科学和临床应用。即将举行的会议的方案中将包括的主题范围将是那些代表该领域最新和最具影响力的进展的主题。多胺在细胞周期调控和细胞死亡中的作用，多胺代谢在分子水平上的调控，多胺参与疾病过程研究中的转基因模型的应用，多胺在真核细胞中的转运，多胺作为癌症化疗和化学预防靶点的干扰作用等。

Polyamines are small cationic alkylamines that are absolutely necessary for cell growth and survival. The predominant, naturally occurring polyamines, spermidine and spermine and their diamine precursor, putrescine are maintained at high intracellular concentrations by a highly regulated metabolic system. The intracellular level of polyamines is also partially regulated by a highly specific, energy-dependent, polyamine transport system. There is considerable interest in the polyamines and their metabolic pathway because many pathological states are accompanied by an alteration in polyamine metabolism and increased polyamine levels, including neoplastic diseases. The rapid increase in the understanding of the molecular roles of the polyamines has led to considerable advances in the development of agents to interfere with polyamine metabolism and function. These agents have shown promise as therapeutic agents and as tools to increase the understanding of polyamine function in prokaryotic and eukaryotic cells. The purpose of the current proposal is to obtain partial funding for the biannual Gordon Conference on Polyamines. The proposed conferences will provide an excellent environment for the free exchange of information and new ideas among senior and junior investigators that will encompass a wide spectrum of interests including basic science to clinical applicability. The range of topics to be included in the programs for the upcoming meetings will be those that represent the most recent and impacting advances in the field. The formal session topics for upcoming 2001 Gordon Conference on Polyamines will include: The role of polyamines in cell cycle regulation and cell death, regulation of polyamine metabolism at the molecular level, the use of transgenic models in the study of polyamine involvement in disease processes, polyamine transport in eukaryotic cells, interference of polyamine function as a target for chemotherapy and chemoprevention in cancer.