EXTRAMULAR RESEARCH FACILITIES IMPROVEMENT PROGRAM

描述（由申请人提供）： 神经系统疾病和创伤是美国和世界的主要健康问题。 神经退行性疾病，如帕金森氏病和阿尔茨海默氏病，使越来越多的老年人变得虚弱。脑和脊髓的创伤性损伤影响所有年龄组。 尽管有巨大的人力和经济成本，但几乎没有有效的治疗神经系统疾病的方法。 为了满足这一国家医疗保健需求，西北大学和范伯格医学院致力于在芝加哥和埃文斯顿校区建立一个能够产生重大临床影响的神经科学社区。 这项工作正在顺利进行，神经科学领域的100多名基础和临床教师每年获得超过3500万美元的联邦研究资金。 该社区的机构战略愿景跨越传统界限，以促进协同作用和合作。 此申请要求资金，以完成在新的罗伯特H。卢瑞医学研究中心。 这样做将允许六个NIH资助的神经科学研究小组，他们有着共同的科学目标和互补的研究技能，可以聚集在相邻的实验室和办公空间中。 目前，这些小组分布在现有基础科学综合体的几个楼层-这种安排阻碍了沟通，共享研究工具和合作。 该计划还通过创建共享核心设施来最大限度地利用空间。 该计划不仅将满足神经退行性疾病的国家研究需求，而且将导致NIH向这六名研究人员提供的超过300万美元/年的直接费用得到更有效的利用。

DESCRIPTION (provided by applicant): Neurological diseases and trauma are major health concerns in the United States and World. Neurodegenerative diseases, like Parkinson's disease and Alzheimer's disease, debilitate an increasingly large fraction of aging population. Traumatic injury to the brain and spinal cord impact all age groups. In spite of the enormous human and economic costs, there are few effective therapies for neurological disorders. In response to this national health care need, Northwestern University and the Feinberg School of Medicine have committed to build a neuroscientific community at the Chicago and the Evanston campuses capable of having a significant clinical impact. This effort is well underway with over 100 basic and clinical faculty in the neurosciences receiving over $35 million in federal research dollars annually. The institutional strategic vision for this community cuts across conventional boundaries to promote synergy and collaboration. This application requests funds to complete a neuroscience floor in the new Robert H. Lurie Medical Research Center. Doing so will allow six NIH-funded neuroscience research groups with shared scientific goals and complementary research skills to be brought together into contiguous laboratory and office space. Currently, these groups are spread over several floors of the existing basic science complex - an arrangement that has impeded communication, sharing of research tools and collaboration. The plan also maximizes space utilization by creating shared core facilities. This plan will not only meet national research needs in neurodegenerative diseases, but will lead to more efficient utilization of over $3M/year in direct costs provided to these six investigators by NIH.