RESEARCH FACILITIES CONSTRUCTION

描述(由申请人提供)： 调查人员提议翻新面积约为7,500平方米。英国《金融时报》位于密歇根大学药学院药学研究大楼二楼和四楼的实验室和办公室。这些计划包括翻新研究实验室空间，以供两类用途。第一个是为药学系的特定教职员工分配场地的翻新。这些“指定用户”实验室将围绕这些实验室的主要研究主题进行设计。这将允许具有相似兴趣的教员共享空间和仪器，从而更有效地利用资源，并将加强研究小组之间的科学对话。除了这个“指定用户”的空间，还有大约1,700平方英尺。英国《金融时报》翻修后的空间被指定为共享核心研究设施，包括细胞和组织培养设施、成像和显微镜实验室、共享冷藏室和冷藏室，以及650平方米。英国《金融时报》核心分子仪器实验室。这些设施将支持广大教职员工对分子药物靶向(即设计、合成和交付有效、高效和选择性药物)的共同目标的研究兴趣，并将构成分子药物靶向中心(CMDT)的基础，该中心将强调生物制药和药物设计、靶向和交付的基于分子和细胞的方法。这里提议的翻修将通过提供基础设施来支持当前资助的研究以及令人兴奋的新的研究人员发起的应用，从而在这些领域做出重要贡献。

DESCRIPTION (provided by applicant): The investigators propose the renovation of approximately 7,500 sq. ft. of laboratories and offices on the second and fourth floors of the Pharmacy Research Building, in the College of Pharmacy at the UM. The plans include renovation of research laboratory space for two categories of use. The first of these is the renovation of space to be assigned to specific faculty members in the Department of Pharmaceutical Sciences. These 'assigned-user' laboratories will be designed around the predominant research themes in those laboratories. This will allow sharing of space and instrumentation among faculty with similar interests, resulting in more efficient use of resources, and will enhance scientific dialogue between research groups. In addition to this 'assigned-user' space, approximately 1,700 sq. ft. of renovated space is designated for shared core research facilities, including cell and tissue culture facilities, an imaging and microscopy laboratory, shared cold room and freezer space, and a 650 sq. ft. Core Molecular Instrumentation Laboratory. These facilities will support research interests across a broad spectrum of faculty members who share the common goal of Molecular Drug Targeting (i.e., the design, synthesis, and delivery of effective, efficient, and selective drugs) and will form the foundation of a Center for Molecular Drug Targeting (CMDT) that will emphasize molecular and cellular based approaches to biopharmaceutics and drug design, targeting and delivery. The renovations proposed here will position to make important contributions in these areas by providing the infrastructure to support current funded research as well as exciting, new investigator initiated applications.