Collaborative Depression Study

描述（由申请人提供）：协同抑郁研究（CDS）促进了情绪障碍的长期前瞻性研究。本修订申请旨在将所有受试者对CDS先证者的预期年度随访时间延长至至少27年。重新获得的资金将使我们能够以以前不可能的方式更好地解决描述中度至重度主要情绪障碍长期病程的总体目标，并进一步调查许多中度至重度情绪障碍患者将发展为终身疾病的一般假设。由于没有类似的数据集来收集这种性质的信息，未来5年持续的数据收集对于获得情绪障碍终身病程的完整视角至关重要，特别是当我们的许多受试者超过65岁时，年龄对情绪障碍病程的影响可以更好地评估。

DESCRIPTION (provided by applicant): The Collaborative Depression Study (CDS) has advanced the long-term prospective study of mood disorders. This revised application seeks to extend the prospective annual follow-up of the CDS probands to at least 27 years for all subjects. Renewed funding will permit us to better address the general aim of describing the long-term course of moderate to severe major mood disorders in ways not previously possible and to further investigate the general hypothesis that many individuals with moderate to severe mood disorders will develop a lifelong illness. Since no similar data set exists to collect information of this nature, the next 5 years of continued data collection are essential to gaining a complete perspective of the lifetime course of mood disorders, particularly as many more of our subjects pass the age of 65 when the effects of aging on the course of mood disorders can be better assessed. The specific aims are to provide long-term, prospective, data that will help investigators to study: (1) the patterns and predictors of course of illness and psychosocial outcome in mood disorders; (2) morbidity, mortality and suicide associated with mood disorders; (3) somatic treatment as a mediating variable of outcome in mood disorders; (4) the longitudinal course of syndromal and sub-syndromal affective symptoms in subjects with unipolar and bipolar depressive disorders; and (5) mood disorders and aging.