Neural Adaptation and Temporal Integration

目前，耳蜗植入设备被设计成以快速的呈现速度(...，即1000脉冲/秒)刺激听神经纤维。和.。刺激率增加，听觉、神经表现出适应的效果。适应的量已经被证明在个体内不同的个体和不同的电极上是不同的。这种适应的神经反应将与中央积分器或中枢听觉系统的输入有关，适应的时间过程可能会影响时间整合的程度。因此，本研究的目的是确定人工耳蜗植入者的外周神经适应与行为时间整合之间的关系。预计来自这项研究的信息将直接应用于个人人工耳蜗器的设置。神经适应性将通过跟踪电诱发复合动作电位(ECAP)对不同长度的快速双相脉冲串的幅度变化来衡量。时态 将通过使用响度平衡程序和使用两个阈值措施来评估整合。电物理和心理物理测量都将沿着电极阵列和在接受人工耳蜗术的个体之间进行。相关和线性回归分析将被用来确定神经适应和时间整合之间的关系。

Currently, cochlear implant devices are designed to stimulate auditory nerve fibers at rapid rates of presentation (...i e ,>1000 pulses/second). With. increased stimulation rates, the auditory., nerve shows the effects of adaptation. The amount of adaptation has been shown to vary across ind_wduals and across electrodes within an individual. This adapted neural response will be related to the input to the central integrator, or central auditory system, and it is possible that the time course of adaptation could affect the degree of temporal integration. The objective of this study, therefore, is to identify the relationship between peripheral neural adaptation and behavioral temporal integration in cochlear implant recipients. It is anticipated that information from this study will have direct application for the setting of individual cochlear implant devices. Neural adaptation will be measured by tracking amplitude changes of the electrically evoked compound action potential (ECAP) to varying lengths of rapid rate biphasic pulse trains. Temporal integration will be assessed through the use of a loudness balancing procedure and through the use of two threshold measures. Both electrophysical and psychophysical measures will be performed along the electrode array and across individual cochlear implant recipients. Correlation and linear regression analyses will be used to determine the relationship between neural adaptation and temporal integration.