Cell Removal during Programmed Cell Death

描述（由申请人提供）：自噬是发生在动物发育过程中的一种重要的程序性细胞死亡形式。自噬的机制尚未得到很好的研究，尽管许多证据表明自噬与帕金森病和癌症等人类疾病有关。类固醇激素20-羟基蜕皮激素在果蝇变态过程中触发唾液腺细胞死亡。唾液腺细胞在蛹形成12小时后开始死亡，16小时后完全死亡。濒死的唾液腺细胞类似于细胞自噬死亡。在这段时间里，这些细胞的形态发生了巨大的变化。本研究的目的是分析唾液腺组织分解过程中细胞的变化，以及发现在唾液腺自噬细胞死亡过程中可能参与重塑过程的新基因。

DESCRIPTION (provided by applicant): Autophagy is a prominent form of programmed cell death that occurs during animal development. The mechanism of autophagy has not been well studied, even though many lines of evidence link autophagy to human diseases such as Parkinson's and cancer. The steroid hormone 20-hydroxyecdysone triggers salivary gland cell death during Drosophila metamorphosis. Salivary gland cell death begins 12 hours after puparium formation and is complete by 16 hours. The cells of dying salivary glands resemble cells undergoing autophagic cell death. These cells undergo dramatic changes in morphology during this time. The aim of this proposal is to analyze cell changes that occur during salivary gland histolysis as well as to identify new genes that may act in the process of remodeling during salivary gland autophagic cell death.