Adherence in Children with Cystic Fibrosis and Asthma

患有慢性病的儿童坚持治疗的比率从10%到83%不等，大多数研究报告称，只有50%的儿童坚持他们的处方治疗方案。由于处方治疗的强度和复杂性，囊性纤维化(CF)和哮喘等儿科肺部疾病的依从性很差。依从性差的后果是严重的，导致急诊室就诊增加，住院次数增加，肺功能下降，寿命缩短。为了有效地解决这些问题，至关重要的是要充分衡量遵守率以及良好疾病管理的关键障碍。尽管一些轶事报道描述了依从性差的可能原因，但没有全面的研究确定患有CF或哮喘的儿童坚持依从性的关键障碍。以前的研究表明，许多因素可能与此有关，包括病程和类型、患者与提供者之间的沟通不畅以及治疗方案的特点。当前建议的主要目标是评估患有CF和哮喘的儿童的依从性问题的程度，系统地比较这两个儿科肺部人群的依从性模式，并确定与依从性差相关的关键障碍。查明这些障碍将直接适用于制定有效的干预措施。

Rates of adherence to treatment for children with chronic illnesses range from 10-83%, with a majority of studies reporting that only 50% of children adhere to their prescribed treatment regimen. Adherence is poor in pediatric pulmonary diseases, such as cystic fibrosis (CF) and asthma, because of the intensity and complexity of prescribed treatments. The consequences of poor adherence are serious, leading to increased emergency room visits, more frequent hospitalizations, declines in pulmonary functioning, and shorter life span. In order to effective address these problems, it is critical to adequately measure rates of adherence, as well as the key barriers to good disease management. Although a few anecdotal reports have described possible reasons for poor adherence, there are no comprehensive studies identifying the key barriers to adherence for children with CF or asthma. Previous research indicates that many factors may be implicated, including course and type of illness, patient-provider miscommunication and regimen characteristics. The primary goal of the current proposal is to assess the extent of adherence problems in children with CF and asthma, systematically compare patterns of adherence in these two pediatric pulmonary populations, and identify the key barriers associated with poor adherence. Identification of these barriers will be directly applicable to the development of effective interventions.