Psychosocial Issues in Umbilical Cord Blood Donation

随着医学的不断进步，干细胞移植成为恶性血液病、骨髓衰竭综合征和实体瘤癌症的一种更成功的治疗选择，对无关供体提供的干细胞的需求将日益增加。虽然这些干细胞传统上是由活着的无关骨髓捐赠者提供的，他们可能面临巨大的身体和心理风险，但目前正在探索收集干细胞的新程序，可能会降低捐赠者的风险。其中一个程序涉及从最近分娩健康婴儿的母亲那里收集脐带血。虽然美国已经建立了几个公共脐带血库来收集和储存脐带血，但目前还没有关于捐赠者在捐赠期间和捐赠后的经验的研究。因此，拟议中的研究的目的是研究的背景，社会心理，和捐赠相关的特征的母亲接触的代表，公共脐带血库，并要求捐赠他们的新生儿的脐带血供未来公众使用。除了描述母体特征外，我们还将研究这些特征的相对影响，以及脐带血库本身的特征和策略（例如，捐赠者选择、教育和同意程序）对捐赠相关结果的影响（例如，决定捐赠，满意度，矛盾心理）。横断面问卷调查数据将在分娩后2-3周或8-9周从1,800名接受冷献血的母亲那里收集，并同意或拒绝由三个公共脐带血库之一捐赠。此外，将在收集产妇数据的同时收集脐带血库特征和策略的数据。此外，将在收集产妇数据的同时收集脐带血库特征和策略的数据。这些数据将使我们能够（a）描述同意接受（或不同意）捐献，（B）检查母亲背景、心理社会和捐献相关结果的关系，（c）检查脐带血库策略和组织因素在预测母亲捐献相关结果中的作用，以及（d）调查母体和库特征对捐赠相关结果的协同效应。

As medical advances continue to make the transplantation of stem cells a more successful treatment option for hematologic malignancies, bone marrow failure syndromes, and solid tumor cancers, there will be an increasing need for such cells supplied by unrelated donors. Although these stem cells have traditionally been supplied by living unrelated bone marrow donors who may face significant physical and psychological risks to donate, new procedures of gathering stem cells that may decrease donor risks are currently being explored. One of these procedures involves the collection of umbilical cord blood from mothers who have recently delivered a healthy infant. Although several public cord blood banks have been established in the U.S. to collect and store umbilical cord blood, no studies of donors experiences during and after donation currently exist. Thus, the proposed study is designed to examine the background, psychosocial, and donation-related characteristics of mothers who are approached by representatives of public umbilical cord blood banks and asked to donate their newborn's cord blood for future public use. In addition to description maternal characteristics, we will also investigate the relative influences of these characteristics, and the characteristics and strategies of cord blood banks themselves (e.g., donor selection, education, and consent procedures) on donation-related outcomes (e.g., decision to donate, satisfaction, ambivalence). Cross-sectional questionnaire data will be gathered either 2-3 weeks or 8-9 weeks post delivery from 1,800 mothers who are approached for cold blood donation- and agree or decline to donate by one of three public cord blood banks. In addition, data on cord blood bank characteristics and strategies will be gathered concurrent with maternal data collection. In addition, data on cord blood bank characteristics and strategies will be gathered concurrent with maternal data collection. These data will allow us to (a) describe the characteristics of mothers who agree to (or do not agree to) donate, (b) examine the relationship of maternal background, psychosocial and donation-related outcomes, (c) examine the role of cord blood bank strategies and organization factors in predicting maternal-donation related outcomes, and (d) investigate the synergistic effects of maternal and bank characteristics on donation-related outcomes.