Project 15.2: Identifying EEG biomarkers and mechanisms for pathological and non-pathological auditory verbal hallucinations and first rank...

项目15.2：确定精神分裂症患者病理性和非病理性听言语幻觉和一级症状的脑电图生物标志物和机制，健康听话者，催眠暗示症状建模。听言语幻觉（AVH）在精神分裂症患者中很常见。然而，“健康的声音听众”也会经历AVH和精神分裂症的其他一级症状（FRS），但不会感到痛苦或残疾，而且确实经常重视这些经历。此外，在健康的催眠反应个体中，AVH和FRS可以使用暗示可靠地建模。症状模型和患者研究表明，在AVH和其他FRS中，辅助运动区（SMA）活动发生了改变。然而，病理性和非病理性AVH期间大脑活动的区别尚不清楚。该博士采用脑电图和症状捕捉方法来描述(i)精神分裂症患者，（ii）健康听话者中AVH和其他FRS所涉及的共同和独特的大脑过程；（iii）使用建议复制第(i)和（ii）项的AVH和FRS的健康个体。主要假设：(a)与建议组相比，精神分裂症患者，然后是健康的语音听者，在SMA和AVH的其他网络成分中表现出更高的基线内在变异性（“不稳定性”）；但是(b)在AVH和其他FRS期间，所有小组的SMA活动都减少了。该学生将参加定期的小组会议，部门研讨会，以及成像和脑电图方法的入门课程，并能够在其他培训机会中培训硕士和博士研究生。

Project 15.2: Identifying EEG biomarkers and mechanisms for pathological and non-pathological auditory verbal hallucinations and first rank symptoms in patients with schizophrenia, healthy voice hearers, and symptom modelling with suggestion in hypnosis Auditory verbal hallucinations (AVH) are common in patients with schizophrenia. However, 'healthy voice hearers' also experience AVH and other first rank symptoms (FRS) of schizophrenia without distress or disability, and indeed often value these experiences. Also, AVH and FRS can be reliably modelled using suggestion in healthy hypnotically responsive individuals. Symptom modelling and patient studies point to altered supplementary motor area (SMA) activity in AVH and other FRS. However, what distinguishes brain activity during pathological and non-pathological AVH is unknown. This PhD employs EEG and symptom capture methods to characterise shared and unique brain processes involved in AVH and other FRS in (i) patients with schizophrenia, (ii) healthy voice hearers; (iii) healthy individuals in whom AVH and FRS of (i) and (ii) are reproduced using suggestion. Main hypotheses: (a) patients with schizophrenia, then healthy voice hearers, show higher baseline intrinsic variability ('instability') in SMA and other network components for AVH compared to the suggestion group; but (b) all groups share reduced SMA activity during AVH and other FRS. The student will attend regular group meetings, departmental seminars, and primers for imaging and EEG methodology, and will be able to train MSc and PhD students amongst other training opportunities.