Rheumatology Training Grant

描述（申请人提供）： 研究培训补助金的目的是为医学博士提供研究的基本背景。和博士博士后这项培训将是迈向学术医学职业生涯的关键一步，并将帮助学员成为独立的调查人员。流变学组的优势是在基础生物医学研究和流行病学及临床研究方面具有相当的深度和生产力。最近的教师招聘有助于分子生物学的实质性优势，其中研究重点是基因转录的调节，成纤维细胞生物学和硬皮病中的胶原蛋白调节，以及mRNA剪接。在免疫学方面，几位资深研究人员研究了淋巴细胞凋亡，自身免疫动物模型中的巨噬细胞缺陷和细胞-细胞粘附。在淀粉样变性中，有淀粉样纤维形成和甲状腺素运载蛋白基因突变的研究。最后，还有骨质疏松症、骨关节炎和类风湿性关节炎的流行病学和结果研究，以及风湿性疾病的卫生经济学和决策分析研究，以及淀粉样变性和硬皮病的临床研究。研究员有多种培训机会，使用最先进的方法研究风湿性疾病的分子基础，发病机制和进展。培训的技术方面将包括分子和细胞生物学、免疫学以及疾病的分析统计和流行病学方法方面的技术。虽然在基础实验室科学和卫生服务研究领域的培训经验之间存在分歧，但这些领域的互动和交叉将使受训者对疾病有更全面的了解。每年申请资助3名受训人员，每名受训人员在培训方案中工作2至3年。波士顿大学的该计划在流变学博士后培训方面有着杰出的记录，许多毕业生都获得了杰出的学术职位。教师提供了一个强大的和经验丰富的方法，并将他们的才华投入到培训补助金。

DESCRIPTION(Provided by Applicant): The purpose of the Research Training Grant is to provide a fundamental background in research to M.D. and Ph.D. post-doctoral fellows. This training will be a critical step towards a career in academic medicine and will help prepare fellows to become independent investigators. A strength of the Rheumatology group is the considerable depth and productivity in both basic biomedical research and in epidemiology and clinical research. Recent faculty recruitments have contributed to substantial strengths in molecular biology where research focuses on regulation of gene transcription, on fibroblast biology and collagen regulation in scleroderma, and on mRNA splicing. In immunology, several senior investigators examine lymphocyte apoptosis, macrophage defects in autoimmune animal models and cell-cell adhesion. In amyloidosis, there are studies of amyloid fibrillogenesis and of mutations in transthyretin genes. Finally, there are outstanding epidemiologic and outcome studies of osteoporosis, osteoarthritis and rheumatoid arthritis and studies of health economics and decision analysis in rheumatic diseases and clinical studies in amyloidosis and scleroderma. Fellows have a diversity of training opportunities to use state of the art approaches in the study of molecular basis, pathogenesis and progress of rheumatic disease. Technical aspects of training will include techniques in molecular and cell biology, immunology, and analytical statistical and epidemiological approaches to disease. Although there will be a dichotomy between training experiences of those in basic bench sciences and in health services research, the interaction and crossfertilization of these areas will allow trainees to gain an overall greater understanding of disease. Funding is requested for 3 trainees in each year of the grant, each trainee to spend two to three years in the training program. The program at Boston University has a distinguished record of post-doctoral training in rheumatology and many graduates have gone on to distinguished academic positions. The faculty provide a strong and experienced approach and will devote their talents to the training grant.